作者： 陈静，王燕峰，王丰 （北京理工大学生命学院，分子医学与生物诊疗工业和信息化部重点实验室）

出处： 生命科学仪器 2023 第21卷 第4期 P18-27

关键词： 阿尔兹海默症；血液标志物；早期诊断；结构生物学

摘要： 阿尔兹海默症（AD）是一种具有漫长病理进程的神经退行性疾病，其发展过程从无症状状态到轻度认知障碍（MCI）,最终进展至痴呆可能持续数十年。当前，AD面临的主要挑战是实现早期诊断。目前，用于AD诊断的传统方法主要包括神经心理学量表测试、成像技术（如MRI和PET）以及脑脊液（CSF）标志物检测。然而， ...

发明人： 邹浙湘，李春，林育康，李木齐，刘家杰

申请人： 北京理工大学珠海学院

申请号： 202310852478.6

申请日期： 2023.07.12

摘要： 本发明涉及安全检测技术领域，且公开了一种机械故障诊断安全检测装置，包括主体机构、操作机构、温控机构和辅助机构，所述操作机构位于主体机构的上方，所述温控机构位于操作机构的下方，所述辅助机构位于温控机构的外侧，所述主体机构包括检测箱、置物槽一和固定块，所述置物槽一固定设置在检测箱内部右端的中部，所述固定 ...

作者： Miao Liu¹;Yuwei Wang¹;Shanshan Tang¹;Wei Wang¹;Axin Liang¹;Aiqin Luo²; （¹ Key Laboratory of Molecular Medicine and Biotherapy, the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China. ² Key Laboratory of Molecular Medicine and Biotherapy, the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China. Electronic address: aqluobit@163.com.）

出处： Bioelectrochemistry (Amsterdam, Netherlands) 2023 Vol.156 P108610

关键词： CdSe@ZnS quantum dots;Electrochemiluminescence sensor;MXene;Molecularly imprinted polymer;Uric acid.

摘要： An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid, based on MXene@Na ...

作者： Jieyu Qi^{1   2   3};Liyan Zhang¹;Fangzhi Tan¹;Yang Zhang⁴;Yinyi Zhou¹;Ziyu Zhang¹;Hongyang Wang⁵;Chaorong Yu⁶;Lulu Jiang⁶;Jiancheng Liu⁶;Tian Chen¹;Lianqiu Wu⁶;Shanzhong Zhang⁶;Sijie Sun^{6   7};Shan Sun⁸;Ling Lu⁹;Qiuju Wang⁵;Renjie Chai^{1   2   3   10}; （¹ State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. ² Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. ³ School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. ⁴ Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China. ⁵ Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China. ⁶ Otovia Therapeutics Inc., Suzhou, 215101, China. ⁷ Fosun Health Capital, Shanghai, 200233, China. ⁸ ENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Fudan University, Shanghai, 200031, China. ⁹ Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China. ¹⁰ Department of Otolaryngology-Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu, 610054, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Pe2306201

关键词： OTOF;gene therapy;nonhuman primate;preclinical research.

摘要： OTOF mutations are the principal causes of auditory neuropathy. There are reports on Otof-related gene therapy in mice, but there is no preclinical re ...

作者： An, Ting¹;Lin, Guangyuan²;Liu, Yang⁴;Qin, Lei²;Xu, Yuquan⁴;Feng, Xudong¹;Li, Chun^1,2,3 （¹Beijing Inst Technol, Inst Biochem Engn, Sch Chem & Chem Engn, Minist Ind & Informat Technol,Dept Chem Engn,Key L, Beijing 100081, Peoples R China.;²Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing 100084, Peoples R China.;³Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China.;⁴Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China.）

出处： METABOLIC ENGINEERING 2023 Vol.80 P207-215

关键词： O-METHYLTRANSFERASES; FLAVONOIDS; EVOLUTION; METABOLISM; CATALYZES; COMPLEX; GENE

摘要： Icariin (ICA) has wide applications in nutraceuticals and medicine with strong anticancer activities. However, the structural complexity and low abund ...

作者： Lai, Ya-Lin¹; Gao, Shun-Qiu¹; Wang, Zhen²; Yan, Ke-Qian¹; Wang, Bang-Jin¹; Yuan, LiMing¹ （¹Department of Chemistry, Yunnan Normal University, Kunming; 650500, China;²Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing; 100081, China）

出处： SSRN 2023

作者： Luo, Yan¹;Jiang, Yaozhu¹;Chen, Linhao¹;Li, Chun^1,2;Wang, Ying¹; （¹ Beijing Inst Technol, Inst Biochem Engn, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Beijing, Peoples R China. ;² Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing, Peoples R China.）

出处： SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023 Vol.8 No.1 P20-32

关键词： BETA-AMYRIN SYNTHASE; SUGAR DONOR SPECIFICITY; STERIC BULK; CATION-PI; SACCHAROMYCES-CEREVISIAE; OXIDOSQUALENE CYCLASES; BIOSYNTHETIC-PATHWAY; CATALYTIC ACTION; AMINO-ACIDS; GLYCOSYLTRANSFERASE

摘要： Triterpenoids are a class of natural products widely used in fields related to medicine and health due to their biological activities such as hepatopr ...

作者： Wang, Xu¹; Jin, Teng¹; Xiong, Jiyuan¹; Zhao, Huiting¹; Hu, Xiaoming¹; Li, Qin¹; Ren, Jie^{2, 3}; Zhao, Yi^{2, 3} （¹Department of Biomedical Engineering, School of Life Science, Beijing Institute of Technology, Beijing, China;²Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China;³Photomedicine Laboratory, Institute of Precision Medicine, Tsinghua University, Beijing, China）

出处： Biomedical Optics Express 2023 Vol.Vol.14 No.No.1 P453-466

作者： Xu, Du-Chang¹; Tang, Xiao-Ying¹; Li, Ao¹; Ma, Jing-Tao²; Xu, Yuan-Qing¹ （¹School of Life Science, Beijing Institute of Technology, Zhongguancun South Street, Beijing; 100081, China;²Aix Marseille Univ, CNRS, Centrale Marseille, M2P2, UMR 7340, Marseille; 13451, France）

出处： Physics of Fluids 2023 Vol.Vol.35 No.No.1

作者： Fan, Yunlong¹;Dai, Rongji¹;Guan, Xuejun¹;Lu, Shuyu¹;Yang, Chunhua¹;Lv, Xuefei¹;Li, Xiaoqiong¹; （¹School of Life Science, Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, Beijing Institute of Technology, Beijing, China）

出处： Journal of Separation Science 2023

摘要： The continuous expansion of nucleic acid detection applications has resulted in constant developments in rapid, low-consumption, and highly automated ...