作者: Wei Kong;Zhen Xie;Xiaokang Shang;Yoshinori Hayashi;Fei Lan;Narengaowa;Shuxuan Zhao;Hui Li;Zhenzhen Quan;Zhou Wu;Hiroshi Nakanishi;Hong Qing;Junjun Ni (Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Department of Physiology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Department of Aging Science and Pharmacology, OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan Department of Pharmacology, Faculty of Pharmacy, Yasuda Women\'s University, Hiroshima, Japan Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Hong Qing and Junjun Ni, Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, China Hong Qing and Junjun Ni, Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.)
出处: Glia 2023 Vol.71 No.12 P2720-2734
关键词: Ly6M;microglia;neuron;NF-κB;zinc finger protein 335
摘要: Zinc finger protein 335 (Zfp335) is a transcription factor that regulates mammalian neurogenesis and neuronal differentiation. It is a causative facto ...
作者: 寇薛帅,谢真,庆宏,倪军军 (北京理工大学生命学院)
出处: 生命科学 2023 第35卷 第11期 P1475-1483
关键词: T淋巴细胞;血脑屏障;阿尔茨海默病;中枢神经系统;免疫细胞
摘要: 阿尔茨海默病(Alzheimer’s disease, AD)作为一种神经退行性疾病,是造成全球痴呆病例的主要原因之一,但有关AD治疗策略的研究无突破性进展。现有研究表明T淋巴细胞向中枢神经系统的浸润/迁移以及血脑屏障的损伤能够促进AD的进程,但作用机制仍不完全明确。本文总结了T淋巴细胞与血脑屏障在 ...
作者: Chun Li1;Zhexiang Zou1;Wenbo Duan2;Jiajie Liu1;Fengshou Gu3;Andrew David Ball3; (1School of Industrial Automation, Beijing Institute of Technology, Zhuhai 519088, China;2Institute of Engineering and Technology, University of Hertfordshire, Hatfield, Hertfordshire AL10 9AB, UK;3Centre for Efficiency and Performance Engineering, University of Huddersfield, Huddersfield HD1 3DH, UK)
出处: Applied Sciences 2023 Vol.13 No.23 P12611
关键词: vibration response;turning process;on-rotor sensing (ORS);dynamic models;finite element analysis (FEA)
摘要: The chatter that occurs during the turning operation, especially when cutting a slender and flexible shaft, determines the surface quality of the work ...
作者: Jian Zhang;Zesen Zhang;Ting Jiang;Zhenyu Zhang;Wei Xu ([a]School of Life Science, Beijing Institute of Technology, No.5 Yard, Zhongguancun South Street, Haidian District, Beijing, 100081, ChinaSchool of Life Science, Beijing Institute of Technology, No.5 Yard, Zhongguancun South Street, Haidian District, Beijing 100081, China[b]State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Zhongguancun Street, Hai Dian District, Beijing, 100084, ChinaState Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Zhongguancun Street, Hai Dian District, Beijing, 100084, China)
出处: Talanta 2023 Vol.260 No.0
摘要: Unsaturated lipids play an essential role in life activities. Identifying and quantifying their carbon-carbon double bond (CC) isomers have become a h ...
作者: 李家兴1;,周丽莹2;,苑峰3;,刘亚玲3;,栾雅琳1;,晁跃辉1; (1北京林业大学草业与草原学院;2北京理工大学生命学院;3内蒙古草业技术创新中心有限公司)
出处: 草地学报 2023 第31卷 第12期 P3617-3625
关键词: MsHB1基因;紫花苜蓿;表达特征;原核表达
摘要: HD-Zip(Homologous structural Domain-leucine Zip,同源结构域-亮氨酸拉链)蛋白是植物特有的转录因子,其中HB1属于HD-ZIP I亚族。通过调节植物体内的内源激素含量变化,HB1转录因子可以提高植物对干旱、高盐等不利环境的抵抗能力。本文为探究紫花苜蓿HB ...
作者: 孙丽超,马晓焉,陈振娅,邹沁,霍毅欣 (北京理工大学生命学院分子医学与生物诊疗重点实验室)
出处: 生物工程学报 2023 第11期 P4718-4729
关键词: 学科交叉;生命科学基础;通识教育;教学改革;生物科学
摘要: “生命科学基础”等生物学通识课程是了解生命科学研究方向和培养生命科学研究兴趣的重要窗口,基于学科交叉实施生命科学基础类课程教学模式改革,培养具有生物学交叉应用能力的复合型人才,对于推动我国生物经济快速发展至关重要。简单的学科叠加式教学方法已经难以让学生发现学科交叉的乐趣,为此,立足于北京理工大学理工 ...
作者: 闫天翼,方伯言,王丽 (北京理工大学生命学院;首都医科大学附属北京康复医院神经康复中心)
出处: 中国神经免疫学和神经病学杂志 2023 第6期 P387-394
关键词: 阿尔茨海默病;轻度认知障碍;无创神经调控;重复经颅磁刺激;经颅电刺激
摘要: 痴呆(dementia)是一种发病率高的以获得性认知功能损害为核心的综合征。遗忘型轻度认知障碍(aMCI)是阿尔茨海默病(Alzheimer\'s disease,AD)的早期阶段。近年来关于AD的大型药物临床试验屡屡宣告失败,而非药物治疗备受重视。无创神经调控是一类非侵入性脑刺激技术(NIBS), ...
作者: 李映辉,唐晓英 (北京理工大学大学生命学院)
出处: 生命科学仪器 2023 第21卷 第4期 P40-45
关键词: 智能手机;PPG信号;信号处理;机器学习;血压估测
摘要: 由于传统血压计的应用场景有限,为了更灵活便捷地估测血压,本文提出了一种基于智能手机光电容积脉搏波(Photoplethysmography, PPG)信号的血压估测方法。利用智能手机采集用户的指端视频并将视频转化为PPG信号,再利用一维U-net网络对PPG信号去噪去基线,对处理完成的信号使用加入残 ...
作者: 赵伟博1,2;,畅文军2;,戴好富2;,吕芳1;,曾艳波2; (1北京理工大学生命学院,生物医药成分分离与分析北京市重点实验室;2中国热带农业科学院热带生物技术研究所,海南省海洋生物资源功能性成分研究与利用重点实验室)
出处: 中国海洋药物 2023 第42卷 第6期 P61-66
关键词: 海洋真菌;Aspergillus insulicola;次级代谢产物;抑菌活性
摘要: 目的 对深海沉积物来源真菌Aspergillus insulicola中的化学成分进行研究。方法 采用正、反相硅胶柱色谱、高效液相色谱等方法对A. insulicola大米发酵产物进行分离提纯;通过质谱、核磁共振等波谱学方法并结合文献数据鉴定其结构。结果 从海洋真菌A. insulicola大米发酵 ...
发明人: 邹浙湘,李春,韩琪,谷丰收
申请人: 北京理工大学珠海学院
申请号: 202311025402.2
申请日期: 2023.08.15
摘要: 本发明公开了一种能有效分析幅值调制AM和相位调制PM共存条件下的非侵入式车床皮带传动系统故障诊断方法。本发明包括以下步骤:S1.采集车床的驱动电机的电流信号并定义为x(t);S2.将采集的x(t)平均划分为N个数据集;S3.依次对N个数据集的第i段电流信号进行离散傅里叶变换得到X(f);S4.计算第 ...