作者： Meng,Xiangyu¹;

出处： 9th International Conference on Energy Materials and Environment Engineering, ICEMEE 2023 Virtual, Online 2023

会议录： Vol.406

摘要： This paper is based on the fundamentals and principles of materials science and resource utilization. In-situ resource utilization (ISRU) can make ful ...

作者： Ma, Yao¹;Zhao, Liping¹;Li, Linsen¹;Zhu, Chao²;Qu, Feng¹; （¹Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, China;²Institute of Quality Standard and Testing Technology for Agro-Products, Shandong Academy of Agricultural Sciences, Jinan, 250100, China）

出处： Microchimica Acta 2023 Vol.190 No.1

摘要： A new type of aptamer-functionalized pH-responsive polymer-modified magnetic nanoparticles (ApMNPs) is introduced for specific enrichment and sensitiv ...

作者： 康宏宇^1,2;，李勤²;，李姣¹;，顾耀文¹;，侯丽¹; （¹中国医学科学院/北京协和医学院医学信息研究所/图书馆；²北京理工大学生命学院）

出处： 中国生物医学工程学报 2023 第42卷 第4期 P453-460

关键词： 多特征融合；药物；疾病；关联预测；图卷积神经网络

摘要： 构建基于药物多特征融合的药物疾病关联预测模型，为药物知识发现提供新思路。借助药物的化学结构、药物-副作用关联、药物-靶标关联的3个特征，构建融合的药物综合相似度及基于MeSH的疾病语义相似度特征表示方法。利用图卷积神经网络模型抽取药物-疾病图数据特征信息，构建基于多特征融合的药物疾病关联预测模型（M ...

作者： Liping Zhao¹;Linsen Li²;Zheng Liu³;Xinjie Wang¹;Ruiqi Yang¹;Zhaofeng Luo⁴;Xiaona Fang⁴;Yunxia Luan¹;CA1 （¹Institute of Quality Standard and Testing Technology of BAAFS, Agricultural Product Quality and Safety Risk Assessment Laboratory of the Department of Agriculture, Beijing 100097, China;²Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, China;³Beijing Institute of Food Inspection and Research (Beijing Municipal Center for Food Safety Monitoring and Risk Assessment), Beijing 100085, China;⁴The Key Laboratory of Zhejiang Province for Aptamers and Theranostic；Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China）

出处： Food Chemistry 2023 Vol.435 P137556

摘要： A new adsorbent based on aptamer functionalized magnetic hydrophobic polymer (MHbPA) was developed for specific and efficient adsorption of alternario ...

作者： Liping Zhao^1,2;Ge Yang³;Chao Zhu⁴;Linsen Li²;Yi Zhao²;Yunxia Luan¹;Feng Qu²;CA1 （¹Institute of Quality Standard and Testing Technology of BAAFS, Agricultural Product Quality and Safety Risk Assessment Laboratory of the Department of Agriculture, Beijing 100097, China;²Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, China;³CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;⁴Institute of Quality Standard and Testing Technology for Agro-products, Shandong Academy of Agricultural Sciences, Jinan 250100, China）

出处： Talanta 2023 Vol.267 P125203

关键词： Aptamer;CE-SELEX;NK exosome;Selection strategy.

摘要： As various disease biomarkers, drugs/biomolecules carriers and physiological function regulator, exosomes play significant roles in various physiologi ...

作者： Fengli Chai¹;Dou Wang¹;Fei Shi²;Wenfu Zheng³;Xiaohui Zhao¹;Yao Chen¹;Cuiping Mao¹;Jiangjiang Zhang^1,4;CA1;Xingyu Jiang¹;CA2 （¹Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, China;²Shenzhen People’s Hospital (The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University), Shenzhen, Guangdong 518020, China;³Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing 100190, China;⁴Key Laboratory of Molecular Medicine and Biotherapy, the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China）

出处： Nano Letters 2023

关键词： Sepsis diagnosis;Inflammation factor detections;Lateral flow immunoassays;Bacterial recognition;Metal−organic frameworks

摘要： Sepsis is an acute systemic infectious syndrome with high fatality. Fast and accurate diagnosis, monitoring, and medication of sepsis are essential. W ...

作者： Ping Ping^1,2,3;Shasha Guan^4,2,3;Chaoxue Ning^5,2,3;Ting Yang^5,2,3;Yali Zhao^5,2,3;Pei Zhang⁶;CA;Zhitao Gao⁷;CA;Shihui Fu^8,9;CA1 （¹General Station for Drug and Instrument Supervision and Control, Joint Logistic Support Force of Chinese People\'s Liberation Army, Beijing, PR China;²Equal contributions.;³Ping Ping, Shasha Guan, Chaoxue Ning and Ting Yang are the co-first authors.;⁴Department of Oncology, Hainan Hospital of Chinese People\'s Liberation Army General Hospital, Sanya, Hainan Province, PR China;⁵Central Laboratory, Hainan Hospital of Chinese People\'s Liberation Army General Hospital, Sanya, Hainan Province, PR China;⁶School of Life Science, Beijing Institute of Technology, Beijing, PR China;⁷School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, PR China;⁸Department of Cardiology, Hainan Hospital of Chinese People\'s Liberation Army General Hospital, Sanya, Hainan Province, PR China;⁹Department of Geriatric Cardiology, Chinese People\'s Liberation Army General Hospital, Beijing, PR China）

出处： Nanomedicine: Nanotechnology, Biology and Medicine 2023 P102708

摘要： Acute myocardial infarction (AMI) is a common cardiovascular condition that progressively results in heart failure. In the present study, we have desi ...

作者： Ge Yang^1,2;Wenjing Liu^3,2;Yi Zhao⁴;Guangyu Jang¹;Chao Zhu^5,6;CA1;Feng Qu⁴;CA2 （¹CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;²Co-first authors.;³Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China;⁴Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, China;⁵Institute of Quality Standard and Testing Technology for Agro-products, Shandong Academy of Agricultural Sciences, Jinan, 250100, China;⁶Shandong Provincial Key Laboratory Test Technology on Food Quality and Safety, Jinan, 250100, China）

出处： Talanta 2023 Vol.267 P125213

关键词： Aptamer;CE-SELEX;Capillary electrophoresis;Competitive binding;RecA.

摘要： The binding site-oriented SELEX strategy is an effective way to promote the functional evolution of aptamers. Here we report a novel aptamer screening ...

作者： 张蕾¹;，陈昕涛^1,2;，白丽娟^1,2;，王志莉³;，冯永君¹;，吴存祥²; （¹北京理工大学生命学院；²中国农业科学院作物科学研究所；³香港中文大学生命科学学院）

出处： 大豆科学 2023 第42卷 第5期 P524-531

关键词： 转录因子；GmbZIP33；非生物胁迫；开花；拟南芥

摘要： 碱性亮氨酸拉链（basic leucine zipper, bZIP）蛋白是真核生物所特有的一类转录因子，广泛参与植物生长、发育、生理代谢的调控过程。为探究大豆bZIP转录因子的功能，本研究通过PCR技术从大豆中克隆bZIP转录因子编码基因GmbZIP33（Glyma.03G219300.1）,利用 ...

作者： Zou, Zhexiang^{1, 2}; Li, Chun^{1, 2}; Shen, Guoji³; Li, Dongqin¹; Gu, Fengshou²; Ball, Andrew David² （¹School of Industrial Automation, Beijing Institute of Technology, Zhuhai, China;²Centre for Efficiency and Performance Engineering, University of Huddersfield, Huddersfield, United Kingdom;³College of Intelligence Science and Technology, National University of Defense Technology, Guangdong, Zhuhai, China）

出处： Measurement and Control (United Kingdom) 2023