作者: Wang,Yun-Feng1;Zhuang,Wan-Ru1;Ma,Xian-Bin1;Nie,Wei-Dong1;Xie,Hai-Yan1; (1School of Life Science, Beijing Institute of Technology, Beijing, 100081, China)
出处: Progress in Biochemistry and Biophysics 2024 Vol.51 No.2 P309-327
摘要: Outer membrane vesicles (OMVs) are nanoscale vesicles secreted by Gram-negative bacteria. As a unique bacterial secretion, OMV secretion can help bact ...
作者: Wang,Meijiao123;Liu,Yawei12456;Sun,Run127;Liu,Fenting891011;Li,Jiaqian12;Yan,Long127;Zhang,Jixiang37;Xie,Xinwei12;Li,Dongxu3;Wang,Yiming127;Li,Shiwen127;Zhu,Xili127;Li,Rong891011;Lu,Falong37;Xiao,Zhenyu212;Wang,Hongmei127; (1The Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;2Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China;3State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;4Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China;5Medical Center of Soochow University, Suzhou, China;6Suzhou Dushu Lake Hospital, Suzhou, China;7University of Chinese Academy of Sciences, Beijing, China;8Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;9National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;10Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China;11Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China;12School of Life Science, Beijing Institute of Technology, Beijing, China)
出处: Nature Genetics 2024 Vol.56 No.2 P294-305
摘要: The human placenta has a vital role in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and func ...
作者: Li,Zijin1;Xie,Hai-Yan2;Nie,Weidong1; (1School of Life Science, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Beijing, 100081, China;2State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, 100191, China)
出处: ChemMedChem 2024
摘要: Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, ...
作者: Wenwei Li1;Yao Xie2;Axin Liang1; (1Key Laboratory of Molecular Medicine and Biotherapy, the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China;2Beijing Dawn Aerospace Bio-Tech Co. Ltd, Beijing 100043, China)
出处: Journal of Physics: Conference Series 2024 Vol.2713 P012076
摘要: Analytical approaches with the features of easy manipulation, cost-effectiveness, and miniature are needed for practice-oriented point-of-care diagnos ...
作者:
Jun Lv MMed1,2,3,4,5;Hui Wang MD1,2,5;Xiaoting Cheng MD1,2,5;Yuxin Chen PhD1,2,5;Daqi Wang PhD1,2,5;Longlong Zhang MMed1,2;Qi Cao BMed1,2;Honghai Tang PhD1,2;Shaowei Hu PhD1,2;Kaiyu Gao PhD6;Mengzhao Xun BMed1,2;Jinghan Wang MD1,2;Zijing Wang BMed1,2;Biyun Zhu PhD1,2;Chong Cui BMed1,2,3,4;Ziwen Gao PhD1,2;Luo Guo PhD1,2;Sha Yu MD1,2;Luoying Jiang BMed1,2,3,4;Yanbo Yin MMed1,2;Jiajia Zhang MMed1,2,3,4;Bing Chen MD1,2;Wuqing Wang MD1,2,7;Renjie Chai DPhil8,9,10,11,12,13,14,7;Zheng-Yi Chen DPhil15,16,17,7;Huawei Li MD1,2,3,4,7;Yilai Shu MD1,2,3,4,7;
出处: The Lancet 2024
摘要: Background Autosomal recessive deafness 9, caused by mutations of the OTOF gene, is characterised by congenital or prelingual, severe-to-complete, bil ...
作者:
Na Chu1,2,3;Xiaobing Wu3;Ziyue Zhao4;Xue Zheng3;Yilin Lu5;Ying Pu3;Yue Wang3;Jiayi Cai3;Lixia Zhang1;Xiaohong He1;Daping Li1;Raymond Jianxiong Zeng3;Yangyang Yu5;Yong Jiang3;
出处: Fundamental Research 2024
关键词: Carbon dioxide reduction;microbial electrosynthesis;gas diffusion electrodes;flow cell;renewable energy storage
摘要: The demand for converting CO2 into fuels or chemicals is on the rise to achieve a carbon-efficient circular economy. Biohybrid CO2
作者: Shuwei Xia1 2 3 4;Dainan Yu1 2 3 4;Yue Wang1 2 3 4;Beijia He1 2 3 4;Yin Rong1 2 3 4;Shuo Chen1 2 3 4;Zhenyu Xiao1 2 3 5;Hongmei Wang1 2 3 4;Hao Wu1 2 3;Long Yan1 2 3; (1 Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. 2 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. 3 Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. 4 University of Chinese Academy of Sciences, Beijing, China. 5 School of Life Science, Beijing Institute of Technology, Beijing, China.)
出处: Cell proliferation 2024 Pe13599
摘要: The embryo-like structures (embryoids) constructed by aggregating embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) have provided revoluti ...
作者: Jieyu Qi1 2 3;Fangzhi Tan1;Liyan Zhang1;Ling Lu4;Shanzhong Zhang5;Yabo Zhai6;Yicheng Lu1;Xiaoyun Qian4;WenXiu Dong5;Yinyi Zhou1;Ziyu Zhang1;Xuehan Yang1;Lulu Jiang5;Chaorong Yu5;Jiancheng Liu5;Tian Chen1;Lianqiu Wu5;Chang Tan5;Sijie Sun5 7;Huaien Song7;Yilai Shu8 9 10;Lei Xu11;Xia Gao4;Huawei Li8 9 10 12;Renjie Chai1 2 3 13 14; (1 State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. 2 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. 3 Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. 4 Department of Otolaryngology-Head and Neck Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, 210008, China. 5 Otovia Therapeutics Inc, Suzhou, 215101, China. 6 School of Medicine, Southeast University, Nanjing, 210009, China. 7 Fosun Health Capital, Shanghai, 200233, China. 8 ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China. 9 Institute of Biomedical Science, Fudan University, Shanghai, 200032, China. 10 NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200032, China. 11 Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, 250022, China. 12 The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China. 13 Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. 14 Southeast University Shenzhen Research Institute, Shenzhen, 518063, China.)
出处: Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Pe2306788
关键词: AAV;OTOF gene therapy;biosafety;clinical trial;hearing recovery.
摘要: Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno-associated virus (AAV)-mediated OTOF gene repl ...
作者: Qin, Lei1,2,3;Ma, Dongshi4;Lin, Guangyuan1,2,3;Sun, Wentao1,2,3;Li, Chun1,2,3,4 (1Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing, Peoples R China.;2Tsinghua Univ, Dept Chem Engn, Beijing, Peoples R China.;3Tsinghua Univ, Key Lab Ind Biocatalysis, Minist Educ, Beijing, Peoples R China.;4Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Minist Ind & Informat Technol,Inst Biochem Engn, Beijing, Peoples R China.)
出处: BIORESOURCE TECHNOLOGY 2024 Vol.395
关键词: LIPID-METABOLISM GENES; SACCHAROMYCES-CEREVISIAE; FERMENTATION; BIOSYNTHESIS; RESISTANCE; PROTEINS; GROWTH
摘要: Altering the fermentation environment provides an effective approach to optimizing the production efficiency of microbial cell factories globally. Her ...
作者: Liang, Axin1; Lv, Tianjian1; Pan, Bingchen1; Zhu, Ziyu1; Haotian, Ruilin1; Zhang, Jiangjiang1; Sun, Liquan1; Luo, Aiqin1 (1Key Laboratory of Molecular Medicine and Biotherapy, The Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing; 100081, China)
出处: SSRN 2024