作者： Zhang,Hui¹²³;Chen,Hong²;Lu,Ling²;Wang,Huan⁴⁷;Zhao,Yuanjin²;Chai,Renjie¹³⁵⁶; （¹State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China;²Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China;³Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China;⁴The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China;⁵Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China;⁶School of Life Science, Beijing Institute of Technology, Beijing, 100081, China;⁷Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, Shenzhen University, Shenzhen, 518060, China）

出处： Advanced Science 2023

摘要： Noise-induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and the targeted delivery of antioxidants t ...

作者： Han,Pei¹;Hou,Hongqu²;Fan,Yunlong²;Wang,Wenjia²;Lü,Xuefei²;Zhang,Wei¹;Li,Xiaoqiong²; （¹Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing, 100094, China;²School of Life, Beijing Institute of Technology, Beijing, 100081, China）

出处： Chinese Journal of Space Science 2023 Vol.43 No.2 P302-309

摘要： Relevant studies on the International Space Station have shown that during the long-term operation of the space station, the existence of microorganis ...

作者： Weidong Zhao¹;Jin Ren²;Min Zhang³;Zhenjie Xue⁴;Tie Wang⁵; （¹ China Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China. Electronic address: zhaoweidong@bit.edu.cn. ² Tianjin Key Laboratory of Life and Health Detection, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin 300384, P.R. China. ³ China Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China. ⁴ Tianjin Key Laboratory of Life and Health Detection, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin 300384, P.R. China. Electronic address: zhenjie86@email.tjut.edu.cn. ⁵ Tianjin Key Laboratory of Life and Health Detection, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin 300384, P.R. China. Electronic address: wangtie@email.tjut.edu.cn.）

出处： STAR protocols 2023 Vol.4 No.4 P102704

关键词： Chemistry;Material Sciences;Microscopy.

摘要： The transformation of superlattice structures into functional devices requires high-quality preparation. Inkjet printing is potentially a cutting-edge ...

作者： Jieyu Qi^1,2,3,4;CA1,2,3,4;Fangzhi Tan^1,4;CA5,6,7,8;Liyan Zhang^1,4;Yinyi Zhou¹;Ziyu zhang¹;Qiuhan Sun¹;Nianci Li¹;Yuan Fang¹;Xin Chen¹;Yunhao Wu¹;Guisheng Zhong^5,6;CA9,10,11,12;Renjie Chai^1,2,3,7,8;CA13,14,15,16 （¹State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China;²Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China;³School of Life Science, Beijing Institute of Technology, Beijing 100081, China;⁴These authors contributed equally.;⁵iHuman Institute, ShanghaiTech University, Shanghai 201210, China;⁶School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China;⁷Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China;⁸Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing 100101, China）

出处： Molecular Therapy 2023

摘要： Inner ear hair cells detect sound vibration through the deflection of mechanosensory stereocilia. Cytoplasmic protein TPRN has been shown to localize ...

作者： Nazhakaiti Palihati¹;Yuanhong Tang¹;Yajuan Yin²;Ding Yu²;Gang Liu²;Zhenzhen Quan¹;Junjun Ni¹;Yan Yan³;Hong Qing^{4   5}; （¹ Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. ² Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. ³ Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China. 15128470659@163.com. ⁴ Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. hqing@bit.edu.cn. ⁵ Department of Biology, Shenzhen MSU-BIT University, Shenzhen, 518172, China. hqing@bit.edu.cn.）

出处： Molecular neurobiology 2023

关键词： Alzheimer’s disease (AD);Amyloid beta (Aβ);Clusterin;Neurodegenerative disorders;Neurotoxicity;Tau.

摘要： In recent years, Clusterin, a glycosylated protein with multiple biological functions, has attracted extensive research attention. It is closely assoc ...

作者： Xinming Li¹;Shuxiang Guo^2,3;Keisuke Suzuki¹;Peng Shi¹;Xiaoliang Jin¹; （¹Graduate School of Engineering, Kagawa University, 2217-20 Hayashi-cho, Takamatsu, Kagawa, Japan ²Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China ³Ministry of Industry and Information Technology, School of Life Science and the Key Laboratory of Convergence Medical Engineering System and Healthcare Technology, Beijing Institute of Technology, Beijing, China）

出处： IEEE Sensors Journal 2023 P1

关键词： Haptic interfaces;Robot sensing systems;Robots;Sensors;Surgery;Safety;Manipulators

摘要： As a promising alternative for minimally invasive vascular surgery, robot-assisted vascular interventional system (VIS) has expressed considerable ben ...

作者： 刘金升，陈振娅，霍毅欣，郭淑元 （北京理工大学生命学院）

出处： 生物技术通报 2023 第10期

关键词： 流式细胞术；荧光激活细胞分选；高通量筛选；定向进化

摘要： 流式细胞术（flow cytometry，FCM）是一种在单细胞水平上对大量细胞进行快速、相对定量的多参数分析技术。基于FCM建立的荧光激活细胞分选术（fluorescence‑activated cell sorting，FACS）可物理分离荧光标记的单细胞，目前已被广泛应用于酶定向进化领域。定向 ...

作者： 李艳茹，周丽莹，董笛，刘亚玲，李舒文，王梦迪，晁跃辉 （北京林业大学草业与草原学院；北京理工大学生命学院；内蒙古草业技术创新中心有限公司）

出处： 草地学报 2023 第11期

关键词： 日本结缕草；酵母文库；SMART技术

摘要： 酵母双杂交和单杂交技术是生物大分子互作和调控研究中的高效分子生物学技术,是蛋白质互作或蛋白质与DNA互作筛选的手段。本研究旨在构建高容量的日本结缕草(Zoysia japonica)酵母文库,以便后续深入挖掘日本结缕草相关基因,进行基因功能及基因网络研究。本研究应用不同组织来源以及不同生长时期的日本 ...

作者： 成祥，耿亚楠，江亚群，赵彤，朱玲玲，邓玉林 （北京理工大学生命学院；军事认知与脑科学研究所）

出处： 生物工程学报 2023 第10期 P4234-4245

关键词： 星形胶质细胞；小胶质细胞；增殖；纯化；分型

摘要： 本研究旨在明确原代培养的星形胶质细胞和小胶质细胞不同代次的生长特性,优化高效获取状态一致细胞的技术方法。将新生乳鼠的脑组织进行原代分离培养胶质细胞,通过细胞增殖检测试剂盒(cell counting kit-8,CCK-8)测定混合胶质细胞增殖曲线,使用流式细胞术检测两类细胞比例,并通过免疫荧光染色 ...

作者： 张瀚文，刘秀云，武睿鹏，李玉娟 （北京理工大学生命学院；解放军总医院京北医疗区北清路门诊部）

出处： 生物工程学报 2023 第10期 P4075-4084

关键词： 太空飞行；模拟空间环境；肠道菌群；代谢产物

摘要： 空间环境中的特殊因素会导致航天员肠道菌群及其代谢产物的失调,对机体会产生系统性的生理影响。本文综述了近年来太空飞行/模拟空间环境对肠道菌群及其代谢产物影响的研究进展。太空飞行/模拟空间环境(space flight/simulated space environment,SF/SPE)可导致侵袭性致 ...