作者： Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang （¹Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China;²School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China;³School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China）

出处： Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023 Vol.291 P122389

关键词： Esterase;Endoplasmic reticulum;Ratiometric;Fluorescent probe

摘要： Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...

发明人： 敬静，高文娟

申请人： 北京理工大学

申请号： 202211321881.8

申请日期： 2022.10.26

摘要： 本发明提供了一种基于核酸适配体的近红外荧光探针及其在制备去甲基化酶检测药物中的应用，属于生物检测分析技术领域。包括修饰的适配体和TO3Acetate；所述适配体的核苷酸序列如SEQ ID No.1所示；所述适配体上的第12、17、22、23和28位中的任一位或者多位碱基上带有m6A修饰基团。基于FT ...

作者： Xu,Liren¹;Yu,Jin¹;Wang,Yunpeng¹;Chen,Yuru²;Zhang,Xiaoli²;Han,Rubing¹;Jing,Jing¹²;Zhang,Rubo¹;Zhang,Xiaoling¹²; （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China）

出处： Dyes and Pigments 2022 Vol.207

摘要： Hypochlorite (ClO−), which is an important reactive oxygen species (ROS) in biology, has attracted scientific attention. Intracellular ClO− are mainly ...

作者： Liang,Chenlu¹;Shu,Wei²;Han,Rubing¹;Kang,Hao¹;Zhang,Xiaoli¹;Jing,Jing¹³;Zhang,Rubo¹;Zhang,Xiaoling¹³; （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electro Photonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Life Sciences and Medicine, Shandong University of Technology, Zibo, 255000, China;³School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China）

出处： Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2022 Vol.277

摘要： Peroxynitrite (ONOO−) is one of quite critical reactive oxygen species that acts critical roles in a number of diverse biological functions and pathol ...

作者： Yu,Jin¹;Shu,Wei²;Kang,Hao¹;Han,Rubing¹;Zhang,Xiaoli¹;Zhang,Rubo¹;Jing,Jing¹³;Zhang,Xiaoling¹³; （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Life Sciences and Medicine, Shandong University of Technology, Zibo, 255000, China;³School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China）

出处： Dyes and Pigments 2022 Vol.204

摘要： The quick coupled reaction of nitric oxide (NO) with superoxide free radicals (·O2−) produces peroxynitrite (ONOO−), it is a powerful biological oxida ...

作者： Han,Rubing¹;Shu,Wei²;Kang,Hao¹;Duan,Qingxia¹;Zhang,Xiaoli¹;Liang,Chenlu¹;Gao,Mengxu¹;Xu,Liren¹;Jing,Jing¹;Zhang,Xiaoling¹; （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electro Photonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Life Sciences and Medicine, Shandong University of Technology, Zibo, 255000, China）

出处： Analytica Chimica Acta 2022 Vol.1203

摘要： Peroxynitrite (ONOO−) is widespread within living organisms and has been implicated in many physiological and pathological processes. Since ONOO− is m ...

作者： Kang, Hao;Shu, Wei;Yu, Jin;Gao, Mengxu;Han, Rubing;Jing, Jing;Zhang, Rubo;Zhang, Xiaoling （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Life Sciences and Medicine, Shandong University of Technology, Zibo, 255000, China）

出处： Sensors and Actuators B: Chemical 2022 Vol.359

摘要： As a regular neurodegenerative disease, Parkinson\'s disease (PD) brings great pain and heavy economic burden to patients. Peroxynitrite (ONOO-) have ...

作者： Zhao,Hengzhi¹;Liu,Yazhou¹;Cui,Jie¹;Yang,Chunlei¹;Gao,Na¹;Jing,Jing¹;Zhang,Xiaoling¹; （¹Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China）

出处： Talanta 2021 Vol.233

摘要： Since ribonuclease H (RNase H) exhibits its importance in a variety of cellular processes. It is necessary to establish strategy for RNase H detection ...

作者： 付云双 （导师：敬静）

学位名称： 硕士

出处： 北京理工大学 2017

关键词： 过氧化亚硝酰；激发态分子内质子转移；荧光探针；内源性

摘要： 过氧化亚硝酰是生物体内非常重要的一种活性氧物质,由一氧化氮和超氧自由基阴离子反应生成,在一些生理和病理过程中具有很高的活性。一方面,过量的过氧化亚硝酰会氧化或硝化细胞内的一些生物分子,如含有酪氨酸残基或硫醇的蛋白质、DNA、含不饱和脂肪酸的脂质等,导致这些生物分子受到伤害,从而引发一系列疾病。另一方 ...