作者：付云双

学位名称：硕士

出处：北京理工大学 2017

关键词：过氧化亚硝酰；激发态分子内质子转移；荧光探针；内源性

摘要：过氧化亚硝酰是生物体内非常重要的一种活性氧物质,由一氧化氮和超氧自由基阴离子反应生成,在一些生理和病理过程中具有很高的活性。一方面,过量的过氧化亚硝酰会氧化或硝化细胞内的一些生物分子,如含有酪氨酸残基或硫醇的蛋白质、DNA、含不饱和脂肪酸的脂质等,导致这些生物分子受到伤害,从而引发一系列疾病。另一方 ...

作者：Kang, Hao;Shu, Wei;Yu, Jin;Gao, Mengxu;Han, Rubing;Jing, Jing;Zhang, Rubo;Zhang, Xiaoling （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Life Sciences and Medicine, Shandong University of Technology, Zibo, 255000, China）

出处：Sensors and Actuators B: Chemical 2022

摘要：As a regular neurodegenerative disease, Parkinson\'s disease (PD) brings great pain and heavy economic burden to patients. Peroxynitrite (ONOO-) have ...

作者：Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang （¹ Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China. ² School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. ³ School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: hellojane@bit.edu.cn. ⁴ School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China. Electronic address: 18363035241@163.com. ⁵ School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: zhangxl@bit.edu.cn.）

出处：Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2023

关键词：Endoplasmic reticulum;Esterase;Fluorescent probe;Ratiometric.

摘要：Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...

作者：Wenjuan Gao;Liren Xu;Jing Jing;Xiaoling Zhang （^a Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China E-mail: hellojane@bit.edu.cn, zhangxl@bit.edu.cn ; ^b School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China）

出处：New Journal of Chemistry 2023

关键词：METTL3-METTL14 COMPLEX;FLUORESCENT-PROBES;STRUCTURAL BASIS;NUCLEAR-RNA;METHYLTRANSFERASE;MASS

摘要：Fat mass and obesity-associated protein (FTO) is a demethylase that participates in N6-methyladenosine (m6A) RNA modification. This demethylase, previ ...

作者：Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang （¹Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China;²School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China;³School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China）

出处：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023

关键词：Esterase;Endoplasmic reticulum;Ratiometric;Fluorescent probe

摘要：Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...

发明人：敬静，高文娟

申请日期：2022.10.26

摘要：本发明提供了一种基于核酸适配体的近红外荧光探针及其在制备去甲基化酶检测药物中的应用，属于生物检测分析技术领域。包括修饰的适配体和TO3Acetate；所述适配体的核苷酸序列如SEQ ID No.1所示；所述适配体上的第12、17、22、23和28位中的任一位或者多位碱基上带有m6A修饰基团。基于FT ...

作者：Feiran Liu¹;Xiaoli Zhang²;Jing Jing¹;CA1;Xiaoling Zhang^1,2;CA2 （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China;²School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, PR China）

出处：Dyes and Pigments 2023

摘要：Golgi stress was the major stress response in the Golgi apparatus, which might be induced the disruption of redox balance and relate to a variety of d ...

作者：Rubing Han¹;Jin Yu¹;Yunpeng Wang¹;Yuru Chen¹;Xiaoli Zhang¹;Rubo Zhang¹;1;Jing Jing^1,2;2;Xiaoling Zhang^1,2;3 （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China;²School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, P. R. China）

出处：Sensors and Actuators B: Chemical 2023

摘要：Parkinson\'s disease (PD) is a neurodegenerative disease common in middle-aged and older individuals. At present, the exact cause is unknown, and the ...

作者：刘飞冉¹;，敬静¹;，张小玲^1,2; （¹北京理工大学化学与化工学院；²北京理工大学医学技术学院）

出处：有机化学 2023

关键词：半胱氨酸；细胞器；靶向定位；荧光探针

摘要：半胱氨酸作为一种重要的内源性小分子硫醇,参与众多生理过程,对细胞内氧化还原水平的调节和生物活性物质的合成具有重要意义.细胞器在生命过程中发挥着不可或缺的作用,不同细胞器具有各自独特的功能,而半胱氨酸在不同细胞器内的作用机制不尽相同.荧光探针的高灵敏度与原位检测能力提供了研究不同细胞器内半胱氨酸的方法 ...

发明人：敬静，康浩，张小玲

申请日期：2023.02.08

摘要：本发明涉及一种用于内质网中HNO检测的双光子荧光探针及其制备方法和应用，属于生物化学分析技术领域。本发明的双光子荧光探针,通过810nm激光对探针进行激发，实现内质网中HNO浓度的检测，可应用于帕金森病模型的早期诊断；本发明的双光子荧光探针，通过飞秒激光激发可以降低背景，延长激发波长，从而适合活体脑 ...