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张小玲

  • 职称:正高级
  • 研究方向:荧光探针
  • 所属院系:化学与化工学院  
  • 成果数量:74条,属于本单位的个人成果74条

Xiaoling Zhang

  • Professional title:professor
  • Research area:fluorescent probe
  • Secondary Instituion:Beijing Insititute of Technology School of Chemistry and Chemical Engineering  
  • Administrative post: subdecanal
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作者: Zang, Tienan1;Wang, Yunpeng1;Zhang, Feng1;Zhang, Xiaoli1;Cao, Yuan1;Jing, Jing1;Zhang, Rubo1;Zhang, Xiaoling11Beijing Inst Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharma, Analyt & Testing Ctr,Beijing Key Lab Photoelect E, Key Lab Cluster Sci Minist Educ,Minist Ind & Info, Beijing 100081, Peoples R China.)

出处: ANALYTICAL CHEMISTRY 2023 Vol.95 No.36 P13438-13445

关键词: BETA-HEXOSAMINIDASE; UNSYMMETRICAL DYADS; FLUOROGENIC PROBES; INHIBITORS

摘要: Generally, different isoforms of proteins exert separate biological functions. However, due to similar structures and identical catalysis functions, d ...

作者: Jingsi Liang;Wei Wei;Zhenqiang Li;Xiaoling Zhang;Wei Liu;Jie Liu;Ji Yang;Yingxi Zuo;Xuepeng Chen;Jixian Sun;Xi Wang;Yi Dong;Mingzhu Zhang;Jingjing Gao;Wensheng Cheng;Bocheng Wang;Hairen Wang (1Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing, China 2School of Astronomy and Space Science, University of Science and Technology of China, Nanjing, China 3Key Laboratory of Photonic Information Technology, Ministry of Industry and Information Technology, School of Optics and Photonics, Beijing Institute of Technology, Beijing, China 4Yangtze Delta Region Academy, Beijing Institute of Technology, Jiaxing, China)

出处: IEEE Transactions on Instrumentation and Measurement 2023 Vol.72 P1-10

关键词: Telescopes;Optical fibers;Microwave measurement;Adaptive optics;Optical surface waves;Optical reflection;Strain

摘要: Large-aperture, single-dish, submillimeter (sub-mm)-wave telescopes are important to our understanding of the universe, but it is a long-term outstand ...

作者: Wenjuan Gao;Liren Xu;Jing Jing;Xiaoling Zhang (a Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China E-mail: hellojane@bit.edu.cn, zhangxl@bit.edu.cn ; b School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China)

出处: New Journal of Chemistry 2023 Vol.47 No.11 P5238-5243

关键词: METTL3-METTL14 COMPLEX;FLUORESCENT-PROBES;STRUCTURAL BASIS;NUCLEAR-RNA;METHYLTRANSFERASE;MASS

摘要: Fat mass and obesity-associated protein (FTO) is a demethylase that participates in N6-methyladenosine (m6A) RNA modification. This demethylase, previ ...

作者: Feiran Liu1;Xiaoli Zhang2;Jing Jing1;CA1;Xiaoling Zhang1,2;CA21Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China;2School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, PR China)

出处: Dyes and Pigments 2023 Vol.219 P111521

摘要: Golgi stress was the major stress response in the Golgi apparatus, which might be induced the disruption of redox balance and relate to a variety of d ...

作者: Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang (1 Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China. 2 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. 3 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: hellojane@bit.edu.cn. 4 School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China. Electronic address: 18363035241@163.com. 5 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: zhangxl@bit.edu.cn.)

出处: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2023 Vol.291 P122389

关键词: Endoplasmic reticulum;Esterase;Fluorescent probe;Ratiometric.

摘要: Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...

作者: Rubing Han1;Jin Yu1;Yunpeng Wang1;Yuru Chen1;Xiaoli Zhang1;Rubo Zhang1;1;Jing Jing1,2;2;Xiaoling Zhang1,2;31Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China;2School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, P. R. China)

出处: Sensors and Actuators B: Chemical 2023 P134455

摘要: Parkinson\'s disease (PD) is a neurodegenerative disease common in middle-aged and older individuals. At present, the exact cause is unknown, and the ...

发明人: 董利,墨越,张小玲,权恒道

申请人: 北京理工大学

申请号: 202211424389.3

申请日期: 2022.11.15

摘要: 本申请提供了一种从非共沸组合物中回收1,1,2,2,3,3,4‑七氟环戊烷的方法,所述非共沸组合物为叔戊醇、苯甲醇和1,1,2,2,3,3,4‑七氟环戊烷的非共沸物组合物,其中,非共沸组合物在催化剂作用下叔戊醇发生脱水反应,通过精馏得到1,1,2,2,3,3,4‑七氟环戊烷馏分;1,1,2,2,3, ...

作者: Hailiang Nie;Wenjia Ji;Jie Cui;Xiaomeng Liang;Xueping Yang;Jie Bai;Xiaoling Zhang (1 Key Laboratory of Public Health Safety of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Public Health, Hebei University Baoding, 071002, Hebei, PR China. Electronic address: niehailiangts@163.com. 2 Key Laboratory of Public Health Safety of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Public Health, Hebei University Baoding, 071002, Hebei, PR China. 3 Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China. 4 Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address: zhangxl@bit.edu.cn.)

出处: Analytica chimica acta 2022 Vol.1236 P340578

关键词: Fluorescent nanoprobe;Human serum albumin;Structural transition.

摘要: Monitoring the content and structural transition of human serum albumin (HSA) is valuable for diagnosing hypoalbuminemia and albuminuria and elucidati ...

作者: Chen, Kun;Zhang, Zheling;Liu, Jian;Huang, Yu;Wang, Dongjie;She, Bin;Liu, Baichen;Zhang, Xiaoling;Zhang, Jian (1School of Materials Science and Engineering, Engineering Research Center of Electronic Information Materials and Devices, Ministry of Education, Guangxi Key Laboratory of Information Materials, Guilin University of Electronic Technology, Guilin, 541004, China;2Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic, Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;3Key Laboratory of Polymeric Materials and Application Technology of Hunan Province, Key Laboratory of Advanced Functional Polymer Materials of Colleges, Universities of Hunan Province, College of Chemistry, Xiangtan University, Xiangtan, 411105, China)

出处: Advanced Materials Interfaces 2022 Vol.9 No.13 P2100395

关键词: HOLE-CONDUCTOR-FREE;SOLVENT;LENGTHS

摘要: Carbon-based, fully printed mesoscopic perovskite solar cells (PMPSCs) possess outstanding environmental stability, which can be fabricated by screen- ...

作者: Shu, Wei1; Yu, Jin2; Li, Zhuohang1; Sun, Xiaoqian1; Wang, Yunpeng2; Wu, Yulong3; Qin, Jie1; Zhang, Yu1; Xiao, Haibin4; Zhang, Xiaoling2; (1School of Life Sciences and Medicine, Shandong University of Technology, Zibo; 255000, China;2Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China;3Department of Radiochemistry, China Institute of Atomic Energy, Beijing; 102413, China;4School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo; 255000, China)

出处: Sensors and Actuators B: Chemical 2022 Vol.369 No.0

关键词: Fluorescent probe;Ratiometric;pH;Bioimaging;Mitophagy

摘要: Intracellular pH is one of the important parameters of cellular metabolism. The function of mitochondria is highly dependent on pH. Developing ratiome ...

张小玲正高级简介

姓名:张小玲
性别:女
出生年月:1963.3
职务职称:教授,博士生导师
联系电话:68913154
传真:010-88875298
电子邮件:zhangxl000@126.com;zhangxl@bit.edu.cn 

主要经历:
   分别于1984年、1987年陕西师范大学化学系获理学学士、硕士学位,随后留校任教。2003年获西北大学分析化学专业博士学位,2005年调入北京理工大学理学院化学系任教授、博士生导师。期间2005年12月应日本筑波产业技术综合研究所(NationalInstitute of Advanced Industrial Science and Technology,AIST)邀请作为特聘研究员从事研究工作,2008-2009年美国佛罗里达大学(University of  Florida)访问教授。主要从事新型光学探针试剂及功能化纳米晶的设计合成及其在分子识别与化学生物传感中的应用研究。

研究方向:
1.        新型光学探针分子的设计、合成
2.        功能化纳米晶及纳米结构的设计、合成、组装
3.        分子识别与化学生物传感

研究内容:
   针对目前环境污染、食品安全、疾病的早期诊断及药物靶向治疗等人类所面对的问题中所必需的高灵敏度、高特异性化学生物识别传感学方法和器件研究,利用光诱导电子转移、电荷转移、能量转移等各种光物理过程,和酶、抗体、单链DNA和核酸识体、信号肽等生物分子识别物质,设计合成性能优异的光学(包括吸光、荧光、发光)探针分子或功能化纳米晶,构建组装针对不同目标物的分子和生物纳米识别体系,实现对生命体系或环境体系中重要目标物(包括阴阳离子,中性小分子,生物大分子,病毒,细菌,肿瘤细胞,病变组织等)的光电化学识别传感,探索识别机制及其化学本质,应用于对生命、环境、食品等复杂体系中具有重要影响力目标物的特异性标记和远程、活体、原位、实时检测或显微成像分析等。 

承担课题:主持或参加国家自然科学基金及其他军工项目多项:
1.        国家自然科学基金资助项目“近红外分子/纳米荧光探针制备及其在肿瘤分子成像分析中的应用研究”,主持人
2.        信号肽介导亚细胞区域靶位近红外Ca2+荧光纳米传感器的研究,国家自然科学基金项目
3.        高选择性硫醇探针的设计合成及分析应用,北京分子科学国家实验室开放课题基金
4.        推进剂装药老化性能表征方法研究,横向
5.        火炸药原材料数据库,横向

主要成果:已发表学术论文百余篇,申请国家发明专利6项,参编或主编出版教材4部,获省科技进步二等奖两项。