李春
发明人: 李春,安婷,冯旭东
申请人: 清华大学,北京理工大学
申请号: 202311504252.3
申请日期: 2023.11.13
摘要: 本发明为一种工程菌及其在合成淫羊藿苷中的应用,提供一种工程化酿酒酵母从头合成淫羊藿苷的方法及应用。本发明利用合成生物学,探究催化山奈酚生成淫羊藿苷的可行性催化顺序:8‑C‑异戊烯基化→4\'‑O‑甲基化→3‑O‑鼠李糖基化→7‑O‑葡萄糖基化。本发明通过表达羽扇豆来源的8‑C异戊烯基转移酶LaPT2 ...
发明人: 刘护,冯旭东,王莹莹,李春
申请人: 北京理工大学
申请号: 202310182086.3
申请日期: 2023.02.20
摘要: 本发明公开了聚磷酸依赖型葡萄糖激酶在五环三萜化合物糖基化修饰中的应用,所述糖基化修饰的糖基供体为蔗糖,所述聚磷酸依赖型葡萄糖激酶用于将副产物果糖转化成果糖‑6‑磷酸,所述聚磷酸依赖型葡萄糖激酶为氨基酸序列如SEQ ID NO:1所示的CgPPGK或氨基酸序列如SEQ ID NO:2所示的Asp‑PP ...
发明人: 冯旭东,简行,李春,孙秋艳,徐文涛
申请人: 北京理工大学
申请号: 202310024443.3
申请日期: 2023.01.07
摘要: 本发明涉及一种人工计算的UDP‑糖基转移酶UGT91H_A1基因及其编码的蛋白。本发明通过对UDP‑糖基转移酶UGT91H亚家族进行祖先酶序列重构,计算获得一种新型UDP‑糖基转移酶的基因UGT91H_A1及其编码的蛋白,在大肠杆菌细胞中成功异源表达,并验证其催化合成常春藤苷元3‑O‑α‑L‑鼠李糖 ...
作者: 陈泉冰1;,曹伟洁1;,李春1,2;,吕波1; (1北京理工大学化学与化工学院生物化工研究所医药分子科学与制剂工程工信部重点实验室;2清华大学化学工程系)
出处: 生物技术通报 2023 第39卷 第1期 P104-114
关键词: GH79家族;催化机理;分子进化;结构解析
摘要: GH79家族的糖苷水解酶在碳水化合物改性、细胞免疫识别和信号传导等方面具有广泛的生理活性和重要的应用前景。然而,目前GH79家族的多样性催化机理仍不清楚,识别底物的结构基础和分子机制尚不清晰。本文总结了近几年GH79家族的研究进展,系统分析了GH79家族酶的来源与分布,通过对酶的序列特征、分子进化关 ...
作者: 杨成佳1;,成旭1;,胡冰1;,吕波1;,李春1,2; (1北京理工大学化学与化工学院;2清华大学化学工程系)
出处: 生物加工过程 2023 第21卷 第1期 P39-49
关键词: 三萜化合物;P450酶;催化机制;催化特异性;CPR适配
摘要: 植物三萜化合物是一类具有6个C5异戊二烯单元的高附加值天然化合物,具有抗炎、护肝、抗肿瘤、抗氧化和降血压等重要药理活性。在三萜化合物生物合成过程中,细胞色素P450酶通过引入羟基、羧基、羰基以及环氧基等官能团,为丰富三萜结构的多样性起到了重要的作用。然而,目前P450酶底物催化 ...
作者: Zou, Zhexiang1, 2; Li, Chun1, 2; Shen, Guoji3; Li, Dongqin1; Gu, Fengshou2; Ball, Andrew David2 (1School of Industrial Automation, Beijing Institute of Technology, Zhuhai, China;2Centre for Efficiency and Performance Engineering, University of Huddersfield, Huddersfield, United Kingdom;3College of Intelligence Science and Technology, National University of Defense Technology, Guangdong, Zhuhai, China)
出处: Measurement and Control (United Kingdom) 2023
作者: Chun Li1;Zhexiang Zou1;Wenbo Duan2;Jiajie Liu1;Fengshou Gu3;Andrew David Ball3; (1School of Industrial Automation, Beijing Institute of Technology, Zhuhai 519088, China;2Institute of Engineering and Technology, University of Hertfordshire, Hatfield, Hertfordshire AL10 9AB, UK;3Centre for Efficiency and Performance Engineering, University of Huddersfield, Huddersfield HD1 3DH, UK)
出处: Applied Sciences 2023 Vol.13 No.23 P12611
关键词: vibration response;turning process;on-rotor sensing (ORS);dynamic models;finite element analysis (FEA)
摘要: The chatter that occurs during the turning operation, especially when cutting a slender and flexible shaft, determines the surface quality of the work ...
作者: An, Ting1;Lin, Guangyuan2;Liu, Yang4;Qin, Lei2;Xu, Yuquan4;Feng, Xudong1;Li, Chun1,2,3 (1Beijing Inst Technol, Inst Biochem Engn, Sch Chem & Chem Engn, Minist Ind & Informat Technol,Dept Chem Engn,Key L, Beijing 100081, Peoples R China.;2Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing 100084, Peoples R China.;3Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing 100084, Peoples R China.;4Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China.)
出处: METABOLIC ENGINEERING 2023 Vol.80 P207-215
关键词: O-METHYLTRANSFERASES; FLAVONOIDS; EVOLUTION; METABOLISM; CATALYZES; COMPLEX; GENE
摘要: Icariin (ICA) has wide applications in nutraceuticals and medicine with strong anticancer activities. However, the structural complexity and low abund ...
作者: Luo, Yan1;Jiang, Yaozhu1;Chen, Linhao1;Li, Chun1,2;Wang, Ying1; (1 Beijing Inst Technol, Inst Biochem Engn, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Beijing, Peoples R China. ;2 Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing, Peoples R China.)
出处: SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023 Vol.8 No.1 P20-32
关键词: BETA-AMYRIN SYNTHASE; SUGAR DONOR SPECIFICITY; STERIC BULK; CATION-PI; SACCHAROMYCES-CEREVISIAE; OXIDOSQUALENE CYCLASES; BIOSYNTHETIC-PATHWAY; CATALYTIC ACTION; AMINO-ACIDS; GLYCOSYLTRANSFERASE
摘要: Triterpenoids are a class of natural products widely used in fields related to medicine and health due to their biological activities such as hepatopr ...
作者: Zhu, Ying1; Zhou, Chen1; Liu, Xia1; Li, Xinying1; Shi, Caifang1; Zhang, Yapeng1; Wang, Ying1; Li, Chun1, 2 (1Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China;2Key Laboratory for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China)
出处: Biotechnology and Bioengineering 2023