仓储作者

[外文会议论文] A Golgi-targeted off-on fluorescent probe for visualizing pH change EI

作者： Li, Zichun^{1, 2}; Jing, Jing^{1, 2}

出处： 4th International Conference on Biomedicine and Bioinformatics Engineering, ICBBE 2024 Kaifeng, China 2024

会议录： Vol.13252

[中文期刊] 揭秘晶体场理论 CA

作者：张可微扬，范梓涵，肖力源，龙海涛，敬静（北京理工大学徐特立学院；北京理工大学化学与化工学院）

出处：大学化学 2024 第39卷第5期 P163-171

关键词：综合实验教学；晶体场理论；配位化学；大环配体；镍配合物

摘要：晶体场理论是配位化学中的基本理论之一,也是本科无机化学教学中的重点和难点内容.本文基于前沿文献报道的镍大环配位化合物,引入多种配体,设计了一个扩展性强的多层次综合性实验.学生通过制备系列镍配合物,观察颜色,测定红外吸收光谱、紫外-可见吸收光谱和有效磁矩,结合课堂讲解与文献阅读,分析配合物的配体组成与 ...

[中文期刊] 揭秘晶体场理论 ——镍大环配合物的制备、表征与性能测定 CA

作者：张可微扬，范梓涵，肖力源，龙海涛，敬静（北京理工大学化学与化工学院；北京理工大学徐特立学院）

出处：大学化学 2024 第5期

关键词：综合实验教学；晶体场理论；配位化学；大环配体；镍配合物

摘要：晶体场理论是配位化学中的基本理论之一，也是本科无机化学教学中的重点和难点内容。本文基于前沿文献报道的镍大环配位化合物，引入多种配体，设计了一个扩展性强的多层次综合性实验。学生通过制备系列镍配合物，观察颜色，测定红外吸收光谱、紫外-可见吸收光谱和有效磁矩，结合课堂讲解与文献阅读，分析配合物的配体组成与 ...

[外文期刊] A lysosome-targeting ratiometric fluorescent probe used to detect Nitroxyl (HNO) in a Parkinson's disease model SCIE EI

作者： Han, Rubing¹; Yu, Jin¹; Wang, Yunpeng¹; Chen, Yuru¹; Zhang, Xiaoli¹; Zhang, Rubo¹; Jing, Jing^{1, 2}; Zhang, Xiaoling^{1, 2} （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China;²School of Medical Technology, Beijing Institute of Technology, Beijing; 100081, China）

出处： Sensors and Actuators B: Chemical 2024

[外文期刊] A novel ratiometric fluorescent probe with high selectivity for lysosomal nitric oxide imaging SCIE EI

作者： Xu, Zhiling¹; Liu, Songtao¹; Xu, Liren¹; Li, Zichun¹; Zhang, Xiaoli^{1, 2}; Kang, Hao¹; Liu, Yifan¹; Yu, Jin¹; Jing, Jing^{1, 2}; Niu, Guangle¹; Zhang, Xiaoling^{1, 2} （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China;²School of Medical Technology, Beijing Institute of Technology, Beijing; 100081, China）

出处： Analytica Chimica Acta 2024

[中文专利] 一种用于内质网中HNO检测的双光子荧光探针及其制备方法和应用

发明人：敬静，康浩，张小玲

申请人：北京理工大学

申请号： 202310140476.4

申请日期： 2023.02.08

摘要：本发明涉及一种用于内质网中HNO检测的双光子荧光探针及其制备方法和应用，属于生物化学分析技术领域。本发明的双光子荧光探针,通过810nm激光对探针进行激发，实现内质网中HNO浓度的检测，可应用于帕金森病模型的早期诊断；本发明的双光子荧光探针，通过飞秒激光激发可以降低背景，延长激发波长，从而适合活体脑 ...

[中文期刊] 细胞器靶向型半胱氨酸荧光探针研究进展 CA 核

作者：刘飞冉¹;，敬静¹;，张小玲^1,2; （¹北京理工大学化学与化工学院；²北京理工大学医学技术学院）

出处：有机化学 2023 第43卷第6期 P2053-2067

关键词：半胱氨酸；细胞器；靶向定位；荧光探针

摘要：半胱氨酸作为一种重要的内源性小分子硫醇,参与众多生理过程,对细胞内氧化还原水平的调节和生物活性物质的合成具有重要意义.细胞器在生命过程中发挥着不可或缺的作用,不同细胞器具有各自独特的功能,而半胱氨酸在不同细胞器内的作用机制不尽相同.荧光探针的高灵敏度与原位检测能力提供了研究不同细胞器内半胱氨酸的方法 ...

[外文期刊] A far red emissive RNA aptamer–fluorophore system for demethylase FTO detection: design and optimization SCIE EI

作者： Wenjuan Gao;Liren Xu;Jing Jing;Xiaoling Zhang （^a Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China E-mail: hellojane@bit.edu.cn, zhangxl@bit.edu.cn ; ^b School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China）

出处： New Journal of Chemistry 2023 Vol.47 No.11 P5238-5243

关键词： METTL3-METTL14 COMPLEX;FLUORESCENT-PROBES;STRUCTURAL BASIS;NUCLEAR-RNA;METHYLTRANSFERASE;MASS

摘要： Fat mass and obesity-associated protein (FTO) is a demethylase that participates in N6-methyladenosine (m6A) RNA modification. This demethylase, previ ...

[外文期刊] Molecular Design Strategy of Protein Isoform-Specific Fluorescent Probes by Considering Molecule in Its Entirety SCIE EI

作者： Zang, Tienan¹;Wang, Yunpeng¹;Zhang, Feng¹;Zhang, Xiaoli¹;Cao, Yuan¹;Jing, Jing¹;Zhang, Rubo¹;Zhang, Xiaoling¹ （¹Beijing Inst Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharma, Analyt & Testing Ctr,Beijing Key Lab Photoelect E, Key Lab Cluster Sci Minist Educ,Minist Ind & Info, Beijing 100081, Peoples R China.）

出处： ANALYTICAL CHEMISTRY 2023 Vol.95 No.36 P13438-13445

关键词： BETA-HEXOSAMINIDASE; UNSYMMETRICAL DYADS; FLUOROGENIC PROBES; INHIBITORS

摘要： Generally, different isoforms of proteins exert separate biological functions. However, due to similar structures and identical catalysis functions, d ...

[外文期刊] A Golgi-targeted fluorescent probe for imaging H₂O₂ and releasing H₂S during Golgi stress SCIE EI

作者： Feiran Liu¹;Xiaoli Zhang²;Jing Jing¹;CA1;Xiaoling Zhang^1,2;CA2 （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, PR China;²School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, PR China）

出处： Dyes and Pigments 2023 Vol.219 P111521

摘要： Golgi stress was the major stress response in the Golgi apparatus, which might be induced the disruption of redox balance and relate to a variety of d ...