作者： Xu, Jiangbing¹; Liu, Lei¹; Yu, Zhen⁷; Fan, Jianbo^{2, 3}; Qin, Wenjing⁴; Liu, Jia⁴; Liu, Xiaoli^{2, 3}; Chen, Ling^{2, 3}; Wu, Meng^{2, 3}; Xiaoyan, Ma⁵; Liu, Ming^{2, 3, 6}; Zhou, Guoyi¹ （¹Institute of Ecology, School of Applied Meteorology, Nanjing University of Information Science and Technology, Nanjing; 210044, China;²State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing; 210008, China;³University of Chinese Academy of Sciences, Beijing; 100049, China;⁴National Engineering and Technology Research Center for Red Soil Improvement, Soil and Fertilizer & Resources and Environment Institute, Jiangxi Academy of Agricultural Sciences, Nanchang; 330200, China;⁵Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing; 100081, China;⁶Institute of Soil Science, Chinese Academy of Sciences, East Beijing Road 71, Nanjing; 210008, China;⁷Nanjing University of Information Science and Technology, China）

出处： SSRN 2024

作者： 王云锋，庄婉茹，马宪彬，聂伟东，谢海燕 （北京理工大学生命学院）

出处： 生物化学与生物物理进展 2024 第51卷 第2期 P309-327

关键词： 细菌外膜囊泡；肿瘤治疗；递送载体；肿瘤疫苗

摘要： 细菌外膜囊泡（outer membrane vesicles,OMVs）是由革兰氏阴性菌分泌的纳米囊泡，主要由细菌外膜和周质成分组成，因此表面富集的病原体相关分子模式（PAMPs）使OMVs能激起强烈的免疫反应。在抗肿瘤研究中，OMVs主要被用于抗肿瘤药物的递送，不仅能增加药物的肿瘤富集还能激活免疫 ...

作者： Jieyu Qi;Liyan Zhang;Fangzhi Tan;Yang Zhang;Yinyi Zhou;Ziyu Zhang;Hongyang Wang;Chaorong Yu;Lulu Jiang;Jiancheng Liu;Tian Chen;Lianqiu Wu;Shanzhong Zhang;Sijie Sun;Shan Sun;Ling Lu;Qiuju Wang;Renjie Chai （State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001 China School of Life Science, Beijing Institute of Technology, Beijing, 100081 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048 China Otovia Therapeutics Inc., Suzhou, 215101 China Otovia Therapeutics Inc., Suzhou, 215101 China Otovia Therapeutics Inc., Suzhou, 215101 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Otovia Therapeutics Inc., Suzhou, 215101 China Otovia Therapeutics Inc., Suzhou, 215101 China Otovia Therapeutics Inc., Suzhou, 215101 China Fosun Health Capital, Shanghai, 200233 China ENT Institute and Otorhinolaryngology, Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Fudan University, Shanghai, 200031 China Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008 China Senior Department of Otolaryngology-Head & Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001 China School of Life Science, Beijing Institute of Technology, Beijing, 100081 China Department of Otolaryngology-Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu, 610054 China）

出处： Advanced Science 2024 Vol.11 No.3 P2306201

关键词： gene therapy;nonhuman primate;OTOF;preclinical research

摘要： OTOF mutations are the principal causes of auditory neuropathy. There are reports on Otof-related gene therapy in mice, but there is no preclinical re ...

作者： Hui Zhang;Hong Chen;Ling Lu;Huan Wang;Yuanjin Zhao;Renjie Chai （State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001 China Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033 China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Department of Biomedical Engineering, Shenzhen University, Shenzhen, 518060 China Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096 China State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096 China Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001 China Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072 China School of Life Science, Beijing Institute of Technology, Beijing, 100081 China）

出处： Advanced Science 2024 Vol.11 No.1 P2305215

关键词： drug delivery;hearing loss;inverse opal;polydopamine;silk fibroin

摘要： Noise-induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and the targeted delivery of antioxidants t ...

作者： Ziyi Liu¹;Hanbing Zhang²;Guodong Hong¹;Xiuli Bi¹;Jun Hu³;Tiancheng Zhang³;Yachun An⁴;Na Guo¹;Fengyue Dong⁴;Yu Xiao⁴;Wen Li¹;Xiaoxu Zhao¹;Bo Chu⁵;Siwei Guo⁴;Xiaohan Zhang¹;Renjie Chai⁶;Xiaolong Fu⁷; （¹ Medical Science and Technology Innovation Center, Institute of Brain Science and Brain-inspired Research, Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. ² Department of Otorhinolaryngology, Qilu Hospital of Shandong University, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, 250012, Shandong, China. ³ Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. ⁴ School of Life Science, Shandong University, Qingdao, 266237, Shandong, China. ⁵ Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250102, Shandong, China. ⁶ State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, Jiangsu, China; Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China; Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, Jiangsu, China; Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China; Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People\'s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China; Southeast University Shenzhen Research Institute, Shenzhen, 518063, Guangdong, China. Electronic address: renjiac@seu.edu.cn. ⁷ Medical Science and Technology Innovation Center, Institute of Brain Science and Brain-inspired Research, Shandong Provincial Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. Electronic address: 210112@sdfmu.edu.cn.）

出处： Molecular therapy : the journal of the American Society of Gene Therapy 2024

摘要： Cisplatin-induced hearing loss is a common side effect of cancer chemotherapy in clinics, however, the mechanism of cisplatin-induced ototoxicity is s ...

作者： 张倍铭¹;，李安一²;，李晓丹³;，孙威¹;，叶建设¹;，马俊³;，吕雪飞²; （¹北京跟踪与通信技术研究所；²北京理工大学生命学院；³北京机械设备研究所）

出处： 分析试验室 2024 第43卷 第2期 P294-300

关键词： 空间微生物；环介导等温扩增；核酸检测；金黄色葡萄球菌；肺炎克雷伯菌；青霉；黑曲霉

摘要： 以金黄色葡萄球菌、肺炎克雷伯菌、青霉、黑曲霉4种典型空间微生物风险菌为试验对象，在筛选得到靶标微生物的特异性环介导等温扩增（LAMP）引物的基础上，成功建立基于LAMP的靶标微生物定量检测技术，检出限为200 copies/μL。该方法表现出良好的检测灵敏度、检测特异性和检测精密度，为空间微生物安全 ...

作者： 齐洁玉，谈方志，张李燕，陆玲，王洪阳，李文妍，刘闻闻，付小龙，贺祖宏，丁小琼，孙珊，方巧军，董耀东，朱学伟，童步升，曹现宝，郭敏，范欣淼，汪芹，马璐，张天虹，于亚峰，李永新，樊建刚，崔勇，吴佩娜，张宏征，唐杰，郭维维，查定军，叶放蕾，何双八，曹卫，杨见明，钱晓云，赵宇，孙敬武，陈晓巍，孙宇，夏明，王秋菊，袁慧军，冯永，孔维佳，杨仕明，王海波，高下，李华伟，徐磊，柴人杰 （东南大学数字医学工程全国重点实验室附属中大医院耳鼻咽喉头颈外科生命科学与技术学院生命与健康高等研究院江苏省生物医学高新技术研究重点实验室；南通大学神经再生联合创新中心；北京理工大学航天中心医院神经内科生命学院；南京大学医学院附属鼓楼医院耳鼻喉头颈外科江苏省医学重点学科(实验室)；中国人民解放军总医院耳鼻咽喉头颈外科医学部；听觉与平衡觉全国重点实验室；国家耳鼻咽喉疾病临床医学研究中心；聋病教育部重点实验室；聋病防治北京市重点实验室；复旦大学附属眼耳鼻喉科医院医学神经生物学国家重点实验室教育部脑科学前沿研究中心；复旦大学生物医学研究所；国家卫健委听觉医学重点实验室；复旦大学脑科学研究院和脑科学协同创新中心；山东大学山东省耳鼻喉医院耳鼻咽喉头颈外科；山东省耳鼻喉研究所；山东第一医科大学/山东省医学科学院医学科技创新中心；武汉大学中南医院耳鼻咽喉头颈外科；东南大学附属中大医院耳鼻咽喉头颈外科；复旦大学附属眼耳鼻喉科医院耳鼻喉科；安徽医科大学第二附属医院耳鼻咽喉头颈外科；中国医科大学附属盛京医院耳鼻咽喉头颈外科；吉林大学中日联谊医院耳鼻咽喉头颈外科；安徽医科大学第一附属医院耳鼻咽喉头颈外科；云南省第一人民医院耳鼻喉科；昆明医科大学第一附属医院耳鼻喉科；中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科；中南大学湘雅二医院耳鼻咽喉头颈外科；南华大学衡阳医学院基础医学院细胞生物学与遗传学教研室细胞应激生物学衡阳市重点实验室；哈尔滨医科大学附属第一医院；苏州大学附属第一医院耳鼻咽喉科；首都医科大学附属北京同仁医院耳鼻咽喉头颈外科；四川省医学科学院·四川省人民医院/电子科技大学附属医院耳鼻咽喉头颈外科；广东省人民医院耳鼻咽喉头颈外科/广东省医学科学院/南方医科大学；南方医科大学珠江医院耳鼻咽喉头颈外科；空军军医大学西京医院耳鼻咽喉-头颈外科；郑州大学第一附属医院耳科；东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科；四川大学华西医院耳鼻咽喉头颈外科；中国科学技术大学附属第一医院耳鼻咽喉头颈外科；华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科；山东第一医科大学附属山东省立医院耳鼻咽喉科；山东省医学科学院医学科技创新中心；山东大学附属山东省立医院耳鼻咽喉科；国家卫生健康委耳鼻咽喉重点实验室；四川大学华西医院罕见病研究院；南华大学衡阳医学院南华大学附属妇幼保健院；中南大学湘雅医院耳鼻咽喉头颈外科；上海人工耳蜗工程技术研究中心；东南大学深圳研究院）

出处： 实用医院临床杂志 2024 第2期

关键词： 遗传性耳聋；基因治疗；临床指南

摘要： 遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰～3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳聋基因治疗的临床试验。其中,由东南大学附属中大医院牵头,联合国内多家医院成功开 ...

作者： Lulu Zheng^1,2;Bo Hu^1,2;Deyao Zhao³;Wenjing Liu^1,4;Qing Liu¹;Yuanyu Huang¹;CA1;Shaobo Ruan¹;CA2 （¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, School of Medical Technology, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing 100081, China;²These authors contributed equally to this work.;³Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China;⁴Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing 101149, China）

出处： Chinese Chemical Letters 2024 Vol.35 No.2 P108647

摘要： Exosomes are membrane-bound nanoscale extracellular vesicles, which produced by almost all organisms. Due to the excellent biocompatibility, long circ ...

作者： Zhang,Ruoyu¹;Chen,Xiaotong¹;Cheng,Yuanyuan¹;Chen,Zixuan¹²;Li,Xiaoqiong¹²;Deng,Yulin¹²; （¹Institute of Engineering Medicine, School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China;²Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China）

出处： Coordination Chemistry Reviews 2024 Vol.502

摘要： Inflammation and neuroinflammation play critical roles in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). Nanomateria ...

作者： Li,Chunhui¹;Ye,Guoguo²;Jiang,Yinghan¹;Wang,Zhiming¹;Yu,Haiyang³;Yang,Minghui¹; （¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing, China;²Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China;³Hangzhou Yalla Information Technology Service Co., Ltd., Hangzhou, China）

出处： Journal of Medical Virology 2024 Vol.96 No.1

摘要： It is widely acknowledged that infectious diseases have wrought immense havoc on human society, being regarded as adversaries from which humanity cann ...