作者： Zheng,Liting¹;Yang,Ge²;Muhammad,Irfan³;Qu,Feng¹; （¹School of Life Science, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China;²CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;³School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China）

出处： TrAC - Trends in Analytical Chemistry 2024 Vol.170

摘要： Exosomes reflect their source cells phenotypic state, making them key biomarkers for tumors, cardiovascular diseases, neurodegenerative diseases, and ...

作者： Essola,Julien Milon¹²³;Zhang,Mengjie¹;Yang,Haiyin¹;Li,Fangzhou²;Xia,Bozhang²³;Mavoungou,Jacques François⁵⁶⁷⁸;Hussain,Abid¹;Huang,Yuanyu¹⁴; （¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, School of Medical Technology, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China;²CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, China;³University of Chinese Academy of Sciences. Beijing 100049, China;⁴Rigerna Therapeutics Co. Ltd., China;⁵Université Internationale de Libreville, Libreville, 20411, Gabon;⁶Central and West African Virus Epidemiology, Libreville, 2263, Gabon;⁷Département de phytotechnologies, Institut National Supérieur d'Agronomie et de Biotechnologie, Université des Sciences et Techniques de Masuku, Franceville, 901, Gabon;⁸Institut de Recherches Agronomiques et Forestiers, Centre National de la Recherche Scientifique et du développement Technologique, Libreville, 16182, Gabon）

出处： Bioactive Materials 2024 Vol.32 P124-146

摘要： Due to its multiple features, including the ability to orchestrate remote communication between different tissues, the exosomes are the extracellular ...

作者： Zhao,Yeyun¹;Yang,Jianhui²;Liang,Chao³;Wang,Zhongjie⁴;Zhang,Yongfeng¹;Li,Gengchen¹;Qu,Jiamin¹;Wang,Xi¹;Zhang,Yahui⁵;Sun,Peng⁶;Shi,Jianbing¹;Tong,Bin¹;Xie,Hai-Yan⁷;Cai,Zhengxu¹;Dong,Yuping¹; （¹Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China;²School of Materials Science and Engineering, Luoyang Institute of Science and Technology, Luoyang, 471023, China;³School of Life Science, Beijing Institute of Technology, Beijing, 100081, China;⁴School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China;⁵Department of Chemistry, School of Science, Xihua University, Chengdu, 610039, China;⁶Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing, 100081, China;⁷State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, 100191, China）

出处： Angewandte Chemie - International Edition 2024 Vol.63 No.5

摘要： Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scal ...

作者： Huang,Zhongming¹;Yang,Tongren²;Yu,Jie¹;Gao,Yijian¹;Weng,Yuhua²;Huang,Yuanyu²;Li,Shengliang¹; （¹College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China;²School of Medical Technology, Institute of Engineering Medicine, Advanced Research Institute of Multidisciplinary Science, School of Life Science, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing, 100081, China）

出处： Biomaterials Science 2024

摘要： Emerging CRISPR-Cas9 systems can rebuild DNA sequences in the genome in a spatiotemporal manner, offering a magic tool for biological research, drug d ...

作者： Moazzam,Muhammad¹;Zhang,Mengjie²;Hussain,Abid²;Yu,Xiaotong³;Huang,Jia⁴;Huang,Yuanyu²⁵; （¹Faculty of Engineering and Science, University of Greenwich, Medway Campus, Kent, Chatham Maritime, ME4 4TB, United Kingdom;²School of Life Science, Advanced Research Institute of Multidisciplinary Science, School of Medical Technology, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China;³Department of Immunology, School of Basic Medical Sciences, Key Laboratory of Medical Immunology of Ministry of Health, Peking University, Beijing, 100191, China;⁴Department of Hepatobiliary Surgery, China−Japan Friendship Hospital, Beijing, 100029, China;⁵Rigerna Therapeutics Co. Ltd., Suzhou, 215127, China）

出处： Molecular Therapy 2024 Vol.32 No.2 P284-312

摘要： Five small interfering RNA (siRNA)-based therapeutics have been approved by the Food and Drug Administration (FDA), namely patisiran, givosiran, lumas ...

作者： Lulu Zheng，Bo Hu，Deyao Zhao，Wenjing Liu，Qing Liu，Yuanyu Huang，Shaobo Ruan （School of Life Science,Advanced Research Institute of Multidisciplinary Science,School of Medical Technology,Key Laboratory of Molecular Medicine and Biotherapy,Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering,Beijing Institute of Technology；Department of Radiation Oncology,The First Affiliated Hospital of Zhengzhou University；Beijing Key Laboratory of Drug Resistance Tuberculosis Research,Beijing Tuberculosis and Thoracic Tumor Research Institute,and Beijing Chest Hospital,Capital Medical University）

出处： Chinese Chemical Letters 2024 第2期

关键词： Exosome；Liposome；Membrane；fusion；Drug；delivery；Disease；treatment

摘要： Exosomes are membrane-bound nanoscale extracellular vesicles,which produced by almost all organisms.Due to the excellent biocompatibility,long circula ...

作者： Li Xiao¹;Li Xiao²;Hafsa Sunniya¹;Jingyi Li¹;Jingyi Li³;Mohib Ullah Kakar¹;Rongji Dai¹;Rongji Dai³;Bo Li¹;Bo Li⁴; （¹Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, China;²School of Medical Technology, Beijing Institute of Technology, Beijing, China;³School of Life Science, Beijing Institute of Technology, Beijing, China;⁴Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, China）

出处： Frontiers in Pharmacology 2024 Vol.15

关键词： Bupleurum marginatum Wall.ex DC;polysaccharides;anti-liver fibrosis;activity study;water extraction and alcohol precipitation

摘要： Bupleurum marginatum Wall.ex DC [Apiaceae] (BM)is widely grown in southwestern China, and the whole plant is used as Traditional Chinese Medicine (TCM ...

作者： Yeyun Zhao;Dr. Jianhui Yang;Chao Liang;Zhongjie Wang;Yongfeng Zhang;Gengchen Li;Jiamin Qu;Xi Wang;Yahui Zhang;Dr. Peng Sun;Prof. Jianbing Shi;Prof. Bin Tong;Prof. Hai-Yan Xie;Prof. Zhengxu Cai;Prof. Yuping Dong （Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China These authors contributed equally to this work. School of Materials Science and Engineering, Luoyang Institute of Science and Technology, Luoyang, 471023 P. R. China These authors contributed equally to this work. School of Life Science, Beijing Institute of Technology, Beijing, 100081 P. R. China School of Medical Technology, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Department of Chemistry, School of Science, Xihua University, Chengdu, 610039 P. R. China Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, 100191 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081 P. R. China）

出处： Angewandte Chemie 2024 Vol.136 No.5 Pe202317431

关键词： Cell Membranes Coating;Fused Ring Structures;Near-Infrared;Organic Room Temperature Phosphorescence;Time-Resolved Imaging

摘要： Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scal ...

作者： Yang Xiu^1,2;Yilong Zhang³;Hongbin Deng¹;Hongkai Li⁴;Yuanqing Xu⁵; （¹School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, China ²Shenzhen Research Institute, Shanghai Jiao Tong University, Shanghai, China ³School of Electrical Engineering and Automation, Fuzhou University, Fuzhou, China ⁴State Key Laboratory of Mechanics and Control for Aerospace Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China ⁵School of Life Science, Beijing Institute of Technology, Beijing, China）

出处： IEEE Transactions on Automation Science and Engineering 2024 P1-11

关键词： Snake robots;Robots;Neural networks;Mathematical models;Formation control;Collaboration;Observers

摘要： For the collaborative formation control problem of a multi-snake robot with uncertain sideslip and lumped unknowns, this study proposed collaborative ...

作者： 刘梦真^1,2;，黄广炎^1,2,3;，张宏^1,2,3;，周宏元⁴;，刘思宇⁵; （¹北京理工大学爆炸科学与技术国家重点实验室；²北京理工大学重庆创新中心现代兵器技术实验室；³北京理工大学爆炸防护与应急处置技术教育部工程研究中心；⁴北京工业大学城市建设学部；⁵北京理工大学生命学院）

出处： 兵工学报 2024 第45卷 第3期 P963-974

关键词： 防护材料；机械折痕检测；特征分段神经网络；几何信息标注

摘要： 防刺服能在恐怖袭击、医闹伤害、违法犯罪等事件中有效保护生命安全，然而在生产制造及穿着使用中易产生机械折痕。立足于防护材料折痕缺陷的快速检测需求，创新性地在图像识别方法中提出特征分段网络结构，实现了小样本驱动下防护材料折痕的快速、精准检测功能。通过引入注意力机制和深度可分离卷积模块，并赋予损失函数与优 ...