作者： Wang,Yun-Feng¹;Zhuang,Wan-Ru¹;Ma,Xian-Bin¹;Nie,Wei-Dong¹;Xie,Hai-Yan¹; （¹School of Life Science, Beijing Institute of Technology, Beijing, 100081, China）

出处： Progress in Biochemistry and Biophysics 2024 Vol.51 No.2 P309-327

摘要： Outer membrane vesicles (OMVs) are nanoscale vesicles secreted by Gram-negative bacteria. As a unique bacterial secretion, OMV secretion can help bact ...

作者： Wang,Meijiao¹²³;Liu,Yawei¹²⁴⁵⁶;Sun,Run¹²⁷;Liu,Fenting⁸⁹¹⁰¹¹;Li,Jiaqian¹²;Yan,Long¹²⁷;Zhang,Jixiang³⁷;Xie,Xinwei¹²;Li,Dongxu³;Wang,Yiming¹²⁷;Li,Shiwen¹²⁷;Zhu,Xili¹²⁷;Li,Rong⁸⁹¹⁰¹¹;Lu,Falong³⁷;Xiao,Zhenyu²¹²;Wang,Hongmei¹²⁷; （¹The Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;²Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China;³State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China;⁴Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China;⁵Medical Center of Soochow University, Suzhou, China;⁶Suzhou Dushu Lake Hospital, Suzhou, China;⁷University of Chinese Academy of Sciences, Beijing, China;⁸Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;⁹National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China;¹⁰Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, China;¹¹Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing, China;¹²School of Life Science, Beijing Institute of Technology, Beijing, China）

出处： Nature Genetics 2024 Vol.56 No.2 P294-305

摘要： The human placenta has a vital role in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and func ...

作者： Li,Zijin¹;Xie,Hai-Yan²;Nie,Weidong¹; （¹School of Life Science, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Beijing, 100081, China;²State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University, Beijing, 100191, China）

出处： ChemMedChem 2024

摘要： Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, ...

作者： Wenwei Li¹;Yao Xie²;Axin Liang¹; （¹Key Laboratory of Molecular Medicine and Biotherapy, the Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China;²Beijing Dawn Aerospace Bio-Tech Co. Ltd, Beijing 100043, China）

出处： Journal of Physics: Conference Series 2024 Vol.2713 P012076

摘要： Analytical approaches with the features of easy manipulation, cost-effectiveness, and miniature are needed for practice-oriented point-of-care diagnos ...

作者： Jun Lv MMed^1,2,3,4,5;Hui Wang MD^1,2,5;Xiaoting Cheng MD^1,2,5;Yuxin Chen PhD^1,2,5;Daqi Wang PhD^1,2,5;Longlong Zhang MMed^1,2;Qi Cao BMed^1,2;Honghai Tang PhD^1,2;Shaowei Hu PhD^1,2;Kaiyu Gao PhD⁶;Mengzhao Xun BMed^1,2;Jinghan Wang MD^1,2;Zijing Wang BMed^1,2;Biyun Zhu PhD^1,2;Chong Cui BMed^1,2,3,4;Ziwen Gao PhD^1,2;Luo Guo PhD^1,2;Sha Yu MD^1,2;Luoying Jiang BMed^1,2,3,4;Yanbo Yin MMed^1,2;Jiajia Zhang MMed^1,2,3,4;Bing Chen MD^1,2;Wuqing Wang MD^1,2,7;Renjie Chai DPhil^{8,9,10,11,12,13,14,7};Zheng-Yi Chen DPhil^15,16,17,7;Huawei Li MD^1,2,3,4,7;Yilai Shu MD^1,2,3,4,7;CA1 （¹ENT Institute and Otorhinolaryngology Department, Eye & ENT Hospital, Fudan University, Shanghai, China;²NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China;³State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China;⁴Institutes of Biomedical Science, Fudan University, Shanghai, China;⁵Joint first authors;⁶Research and Development Department, Shanghai Refreshgene Therapeutics, Shanghai, China;⁷Joint last authors;⁸State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China;⁹Department of Otolaryngology Head and Neck Surgery of Zhongda Hospital, Southeast University, Nanjing, China;¹⁰Advanced Institute for Life and Health, Southeast University, Nanjing, China;¹¹Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China;¹²Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, China;¹³Department of Neurology of Aerospace Center Hospital, Beijing Institute of Technology, Beijing, China;¹⁴School of Life Science, Beijing Institute of Technology, Beijing, China;¹⁵Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, USA;¹⁶Graduate Program in Speech and Hearing Bioscience and Technology and Program in Neuroscience, Harvard Medical School, Boston, MA, USA;¹⁷Eaton-Peabody Laboratory, Massachusetts Eye and Ear, Boston, MA, USA）

出处： The Lancet 2024

摘要： Background Autosomal recessive deafness 9, caused by mutations of the OTOF gene, is characterised by congenital or prelingual, severe-to-complete, bil ...

作者： Na Chu^1,2,3;Xiaobing Wu³;Ziyue Zhao⁴;Xue Zheng³;Yilin Lu⁵;Ying Pu³;Yue Wang³;Jiayi Cai³;Lixia Zhang¹;Xiaohong He¹;Daping Li¹;Raymond Jianxiong Zeng³;Yangyang Yu⁵;Yong Jiang³;CA1 （¹CAS Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;²University of Chinese Academy of Sciences, Beijing 100049, China;³Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China;⁴School of Life Science, Beijing Institute of Technology, Beijing 100081, China;⁵Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, China）

出处： Fundamental Research 2024

关键词： Carbon dioxide reduction;microbial electrosynthesis;gas diffusion electrodes;flow cell;renewable energy storage

摘要： The demand for converting CO₂ into fuels or chemicals is on the rise to achieve a carbon-efficient circular economy. Biohybrid CO₂

作者： Shuwei Xia^{1   2   3   4};Dainan Yu^{1   2   3   4};Yue Wang^{1   2   3   4};Beijia He^{1   2   3   4};Yin Rong^{1   2   3   4};Shuo Chen^{1   2   3   4};Zhenyu Xiao^{1   2   3   5};Hongmei Wang^{1   2   3   4};Hao Wu^{1   2   3};Long Yan^{1   2   3}; （¹ Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ⁴ University of Chinese Academy of Sciences, Beijing, China. ⁵ School of Life Science, Beijing Institute of Technology, Beijing, China.）

出处： Cell proliferation 2024 Pe13599

摘要： The embryo-like structures (embryoids) constructed by aggregating embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) have provided revoluti ...

作者： Jieyu Qi^{1   2   3};Fangzhi Tan¹;Liyan Zhang¹;Ling Lu⁴;Shanzhong Zhang⁵;Yabo Zhai⁶;Yicheng Lu¹;Xiaoyun Qian⁴;WenXiu Dong⁵;Yinyi Zhou¹;Ziyu Zhang¹;Xuehan Yang¹;Lulu Jiang⁵;Chaorong Yu⁵;Jiancheng Liu⁵;Tian Chen¹;Lianqiu Wu⁵;Chang Tan⁵;Sijie Sun^{5   7};Huaien Song⁷;Yilai Shu^{8   9   10};Lei Xu¹¹;Xia Gao⁴;Huawei Li^{8   9   10   12};Renjie Chai^{1   2   3   13   14}; （¹ State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China. ² Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. ³ Department of Neurology, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. ⁴ Department of Otolaryngology-Head and Neck Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, 210008, China. ⁵ Otovia Therapeutics Inc, Suzhou, 215101, China. ⁶ School of Medicine, Southeast University, Nanjing, 210009, China. ⁷ Fosun Health Capital, Shanghai, 200233, China. ⁸ ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China. ⁹ Institute of Biomedical Science, Fudan University, Shanghai, 200032, China. ¹⁰ NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200032, China. ¹¹ Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, 250022, China. ¹² The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China. ¹³ Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People\'s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. ¹⁴ Southeast University Shenzhen Research Institute, Shenzhen, 518063, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Pe2306788

关键词： AAV;OTOF gene therapy;biosafety;clinical trial;hearing recovery.

摘要： Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno-associated virus (AAV)-mediated OTOF gene repl ...

作者： Qin, Lei^1,2,3;Ma, Dongshi⁴;Lin, Guangyuan^1,2,3;Sun, Wentao^1,2,3;Li, Chun^1,2,3,4 （¹Tsinghua Univ, Ctr Synthet & Syst Biol, Beijing, Peoples R China.;²Tsinghua Univ, Dept Chem Engn, Beijing, Peoples R China.;³Tsinghua Univ, Key Lab Ind Biocatalysis, Minist Educ, Beijing, Peoples R China.;⁴Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Minist Ind & Informat Technol,Inst Biochem Engn, Beijing, Peoples R China.）

出处： BIORESOURCE TECHNOLOGY 2024 Vol.395

关键词： LIPID-METABOLISM GENES; SACCHAROMYCES-CEREVISIAE; FERMENTATION; BIOSYNTHESIS; RESISTANCE; PROTEINS; GROWTH

摘要： Altering the fermentation environment provides an effective approach to optimizing the production efficiency of microbial cell factories globally. Her ...

作者： Liang, Axin¹; Lv, Tianjian¹; Pan, Bingchen¹; Zhu, Ziyu¹; Haotian, Ruilin¹; Zhang, Jiangjiang¹; Sun, Liquan¹; Luo, Aiqin¹ （¹Key Laboratory of Molecular Medicine and Biotherapy, The Ministry of Industry and Information Technology, School of Life Science, Beijing Institute of Technology, Beijing; 100081, China）

出处： SSRN 2024