敬静
作者: Han, Rubing1; Yu, Jin1; Wang, Yunpeng1; Chen, Yuru1; Zhang, Xiaoli1; Zhang, Rubo1; Jing, Jing1, 2; Zhang, Xiaoling1, 2 (1Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China;2School of Medical Technology, Beijing Institute of Technology, Beijing; 100081, China)
出处: Sensors and Actuators B: Chemical 2024
发明人: 敬静,康浩,张小玲
申请人: 北京理工大学
申请号: 202310140476.4
申请日期: 2023.02.08
摘要: 本发明涉及一种用于内质网中HNO检测的双光子荧光探针及其制备方法和应用,属于生物化学分析技术领域。本发明的双光子荧光探针,通过810nm激光对探针进行激发,实现内质网中HNO浓度的检测,可应用于帕金森病模型的早期诊断;本发明的双光子荧光探针,通过飞秒激光激发可以降低背景,延长激发波长,从而适合活体脑 ...
作者: 刘飞冉1;,敬静1;,张小玲1,2; (1北京理工大学化学与化工学院;2北京理工大学医学技术学院)
出处: 有机化学 2023 第43卷 第6期 P2053-2067
关键词: 半胱氨酸;细胞器;靶向定位;荧光探针
摘要: 半胱氨酸作为一种重要的内源性小分子硫醇,参与众多生理过程,对细胞内氧化还原水平的调节和生物活性物质的合成具有重要意义.细胞器在生命过程中发挥着不可或缺的作用,不同细胞器具有各自独特的功能,而半胱氨酸在不同细胞器内的作用机制不尽相同.荧光探针的高灵敏度与原位检测能力提供了研究不同细胞器内半胱氨酸的方法 ...
作者: Wenjuan Gao;Liren Xu;Jing Jing;Xiaoling Zhang (a Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photo-electronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China E-mail: hellojane@bit.edu.cn, zhangxl@bit.edu.cn ; b School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China)
出处: New Journal of Chemistry 2023 Vol.47 No.11 P5238-5243
关键词: METTL3-METTL14 COMPLEX;FLUORESCENT-PROBES;STRUCTURAL BASIS;NUCLEAR-RNA;METHYLTRANSFERASE;MASS
摘要: Fat mass and obesity-associated protein (FTO) is a demethylase that participates in N6-methyladenosine (m6A) RNA modification. This demethylase, previ ...
作者: Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang (1 Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China. 2 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. 3 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: hellojane@bit.edu.cn. 4 School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China. Electronic address: 18363035241@163.com. 5 School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China. Electronic address: zhangxl@bit.edu.cn.)
出处: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2023 Vol.291 P122389
关键词: Endoplasmic reticulum;Esterase;Fluorescent probe;Ratiometric.
摘要: Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...
作者:
Rubing Han1;Jin Yu1;Yunpeng Wang1;Yuru Chen1;Xiaoli Zhang1;Rubo Zhang1;
出处: Sensors and Actuators B: Chemical 2023 P134455
摘要: Parkinson\'s disease (PD) is a neurodegenerative disease common in middle-aged and older individuals. At present, the exact cause is unknown, and the ...
作者:
Feiran Liu1;Xiaoli Zhang2;Jing Jing1;
出处: Dyes and Pigments 2023 Vol.219 P111521
摘要: Golgi stress was the major stress response in the Golgi apparatus, which might be induced the disruption of redox balance and relate to a variety of d ...
作者: Bingpeng Guo;Tianjiao Shen;Yifan Liu;Jing Jing;Changxiang Shao;Xiaoling Zhang (1Shandong Provincial Key Laboratory of Molecular Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, PR China;2School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, PR China;3School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271099, PR China)
出处: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2023 Vol.291 P122389
关键词: Esterase;Endoplasmic reticulum;Ratiometric;Fluorescent probe
摘要: Esterase is primarily distributed in the endoplasmic reticulum (ER) and often overexpressed in cancer cells. Therefore, the detection of esterase in E ...
作者: Zang, Tienan1;Wang, Yunpeng1;Zhang, Feng1;Zhang, Xiaoli1;Cao, Yuan1;Jing, Jing1;Zhang, Rubo1;Zhang, Xiaoling1 (1Beijing Inst Technol, Sch Chem & Chem Engn,Key Lab Med Mol Sci & Pharma, Analyt & Testing Ctr,Beijing Key Lab Photoelect E, Key Lab Cluster Sci Minist Educ,Minist Ind & Info, Beijing 100081, Peoples R China.)
出处: ANALYTICAL CHEMISTRY 2023 Vol.95 No.36 P13438-13445
关键词: BETA-HEXOSAMINIDASE; UNSYMMETRICAL DYADS; FLUOROGENIC PROBES; INHIBITORS
摘要: Generally, different isoforms of proteins exert separate biological functions. However, due to similar structures and identical catalysis functions, d ...
作者: Liu,Feiran1;Jing,Jing1;Zhang,Xiaoling12; (1School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China;2School of Medical Technology, Beijing Institute of Technology, Beijing, 100081, China)
出处: Chinese Journal of Organic Chemistry 2023 Vol.43 No.6 P2053-2060
摘要: As an important endogenous biothiol, cysteine is involved in various physiological processes. Besides, cysteine also plays an important role in the re ...