仓储作者

[中文期刊] 高效液相色谱法测定大鼠血浆中氯解磷定含量及药代动力学研究 CA CSCD 核

作者：蔡啟梅¹;，冯数橙²;，王涛²;，全东琴²;，王永安²;，申辽²;，马兵¹; （¹北京理工大学化学与化工学院医药分子科学与制剂工程工信部重点实验室；²军事科学院军事医学研究院毒物药物研究所高毒物质对抗药物研究国家重点实验室）

出处：分析试验室 2023 第42卷第2期 P167-171

关键词：高效液相色谱；氯解磷定；含量测定；药代动力学

摘要：建立了高效液相色谱法（HPLC）测定血浆中氯解磷定（PAM）的含量，研究了不同给药方式对大鼠体内药代动力学行为的影响。优化条件为：色谱柱CAPCELL PAK C18 MGⅢ（250 mm×4.6 mm, 5μm），以5 mmol/L正庚烷磺酸钠溶液（含体积比0.12%三氟乙酸）-乙腈为流动相进行梯 ...

[外文期刊] Model Validation of Rigid Body Tilting of Deformed Spinning Discs with Spline-Guided Constraints SCIE EI

作者： Xue, J.¹;Ma, B.^1,2;Chen, M.^1,2;Yu, L.¹;Zheng, L.³ （¹Beijing Inst Technol, Sch Mech Engn, Beijing 10010, Peoples R China.;²Beijing Inst Technol, Key Lab Sci & Technol Natl Def, Beijing 10010, Peoples R China.;³China Natl Heavy Duty Truck Grp, Automot Res Inst, Jinan 250010, Shandong, Peoples R China.）

出处： EXPERIMENTAL TECHNIQUES 2023

关键词： STABILITY; PLATES

摘要： This paper analyzes the rigid body tilting of the spinning disc with a spline-guided boundary condition. Firstly, a comprehensive dynamic model of the ...

[外文期刊] Determination of pralidoxime chloride in rat plasma by high-performance liq uid chromatography and study of its pharmacokinetic EI

作者： Cai, Qimei¹; Feng, Shucheng²; Wang, Tao²; Quan, Dongqin²; Wang, Yongan²; Shen, Liao²; Ma, Bing¹ （¹School of Chemistry and Chemical Engineering, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing; 100081, China;²State Key Laboratory of Highly Toxic Substances for Anti-Drug Research, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing; 100850, China）

出处： Chinese Journal of Analysis Laboratory 2023 Vol.Vol.42 No.No.2 P167-171

[中文期刊] 新型醛糖还原酶抑制剂的设计合成及活性评价 CA CSCD 核

作者：刘文超¹;，张晓楠¹;，许龙¹;，张新¹;，秦华²;，朱长进¹;，马兵¹; （¹北京理工大学化学与化工学院；²北京天衡军威医药技术开发有限公司）

出处：沈阳药科大学学报 2023 第40卷第1期 P18-28

关键词：醛糖还原酶抑制剂；糖尿病并发症；分子对接

摘要：目的设计合成一系列靛红衍生物，研究其对醛糖还原酶的抑制活性和选择性。方法以5-溴靛红为起始原料合成5′-溴螺[[1,3]二氧戊环-2,3′-吲哚啉]-2′-酮的三环骨架，然后经N烷基化反应、Suzuki或Heck偶联、水解合成了目标化合物。测定目标化合物对醛糖还原酶的抑制活性和选择性，通过计算机 ...

[外文期刊] A 'cell Space Station' for Spatiotemporal Molecular Manipulation of Immune Checkpoint SCIE EI

作者： Li, Lingyun¹; Li, Mengzhen¹; Wang, Minxuan¹; Zhang, Limin¹; Yu, Yao¹; Zhang, Jiatao¹; Ma, Bing¹; Wang, Weizhi¹ （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China）

出处： ACS Nano 2022 Vol.Vol.16 No.No.10 P16332-16342

[外文期刊] A composite peptide-supramolecular microneedle system for melanoma immunotherapy SCIE EI

作者： Li, Mengzhen¹; Wang, Minxuan¹; Li, Lingyun¹; Zhang, Limin¹; Ma, Bing¹; Wang, Weizhi¹ （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing; 100081, China）

出处： Nano Research 2022

[外文期刊] Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and alpha-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications SCIE

作者： Zhang, Xiaonan^1,2;Xu, Long^1,2;Chen, Huan^1,2;Zhang, Xin^1,2;Lei, Yanqi^1,2;Liu, Wenchao^1,2;Xu, Hulin^1,2;Ma, Bing^1,2;Zhu, Changjin^1,2; （¹ Beijing Inst Technol, Beijing Key Lab Photoelect, Key Lab Cluster Sci, Minist Educ China, Beijing 100081, Peoples R China. ;² Beijing Inst Technol, Electrophoton Convers Mat, Sch Chem & Chem Engn, Beijing 100081, Peoples R China.）

出处： JOURNAL OF MEDICINAL CHEMISTRY 2022

关键词： ANTIDIABETIC AGENTS; IN-VITRO; DERIVATIVES; ENZYME; HIV; INFECTIVITY; INSULIN; TARGETS; BINDING; SERIES

摘要： We designed a novel series of bifunctional inhibitors of alpha-glucosidase and aldose reductase (ALR2) based on the structure of hydroxychalcone. The ...

[外文期刊] Peptide-Based Nanomaterials for Tumor Immunotherapy

作者： Lingyun Li¹;Bing Ma¹;Weizhi Wang¹; （¹ School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.）

出处： Molecules (Basel, Switzerland) 2020 Vol.26 No.1 P132

关键词： immune checkpoint blockade;peptide screening;peptide self-assembly;peptide-based nanomaterials.

摘要： With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a resear ...

[中文专利] 一系列苯并噁唑酮类衍生物的结构、制备方法及用途

发明人：朱长进，马兵，张新

申请人：北京理工大学

申请号： 202011441028.0

申请日期： 2020.12.08

摘要：本发明公开了一系列苯并噁唑酮类衍生物的结构、制备方法及用途，即提供了化合物Ⅰ所示苯并噁唑酮类化合物结构、合成方法、及其药学上可以接受的盐或它们的混合物在制备预防和/或治疗糖尿病并发症药物中的用途。这类化合物作为醛糖还原酶抑制剂和抗氧化剂，还具有降血糖效果。该类化合物可以降血糖，抑制醛糖还原酶的活性， ...

[中文学位论文] 基于喹喔啉酮结构的醛糖还原酶抑制剂设计合成与构效关系研究

作者：王杏（导师：马兵）

学位名称：硕士

出处：北京理工大学 2017

关键词：醛糖还原酶抑制剂；喹喔啉酮；延长碳链；抑制活性

摘要：糖尿病是一类机体代谢异常疾病,严重影响人类健康和生活,以高血糖为主要标志。人体长期处于高血糖状态下,不可避免地诱发多种慢性并发症,如:视网膜病变、周围神经病变、肾微血管病变等,这些并发症是糖尿病患者所面临的最大威胁。研究表明,糖尿病并发症与葡萄糖在多元醇通路中的代谢异常有着密切关系,醛糖还原酶抑制剂 ...