作者： Zhou, Jiao-Shuai^1,2;Wen, Hong-Liang^1,2;Yu, Ming-Jia¹ （¹Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 100081, Peoples R China.;²Beijing Inst Technol, Yangtze Delta Reg Acad, Key Lab Med Mol Sci & Pharmaceut Engn, Jiaxing 314019, Peoples R China.）

出处： INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024 Vol.25 No.10

关键词： PROTEIN; DESIGN

摘要： Phytophthora infestans (Mont.) de Bary, the oomycotic pathogen responsible for potato late blight, is the most devastating disease of potato productio ...

作者： Zeng, Wen^1,2;Wang, Yifei¹;Gao, Rui¹;Wen, Hongliang^1,2;Yu, Mingjia¹ （¹Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 100081, Peoples R China.;²Beijing Inst Technol, Yangtze Delta Reg Acad, Key Lab Med Mol Sci & Pharmaceut Engn, Jiaxing 314019, Peoples R China.）

出处： JOURNAL OF MEDICINAL CHEMISTRY 2024 Vol.67 No.16 P14574-14585

关键词： MOLECULAR-DYNAMICS SIMULATION; PROTEIN; INTEGRATION; GENERATION; PREDICTION; MODEL

摘要： Cannabidiol (CBD) and Delta 9-tetrahydrocannabinol (THC), the main components of Cannabis sativa plants, have attracted a significant amount of attent ...

作者： Kalsoom, Iqra¹;Shehzadi, Kiran¹;Li, Han-sheng¹;Wen, Hong-liang¹;Yu, Ming-jia¹ （¹Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Minist Ind & Informat Technol, Beijing 10081, Peoples R China.）

出处： TOPICS IN CURRENT CHEMISTRY 2024 Vol.382 No.2

关键词： PARKINSONS-DISEASE; NEUROPATHIC PAIN; CONSTITUENT CANNABIDIOL; ALLOSTERIC MODULATOR; THERAPEUTIC AGENTS; INVERSE AGONIST; RAT MODEL; CANNABINOIDS; RECEPTORS; GPR18

摘要： Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained p ...

发明人： 温鸿亮，唐紫云，刘美华

申请人： 北京理工大学

申请号： 202311616545.0

申请日期： 2023.11.30

摘要： 本发明提供一种(S)‑5‑氧代哌啶‑2‑羧酸酯的制备方法，涉及药物化学领域。该方法以5‑羟甲基糠醛为起始原料，经扩环、氢化、氧化、酯化、酶拆分等步骤得到(S)‑5‑氧代哌啶‑2‑羧酸酯。该方法原料价格廉价、操作简便、反应条件绿色环保，产品纯度高，具有良好的工业应用前景。

发明人： 温鸿亮，王浩飞，尹江林，高杰

申请人： 北京理工大学

申请号： 202311238029.9

申请日期： 2023.09.22

摘要： 本发明涉及一种阿维巴坦单钠盐的新晶型及其制备方法。该方法制备阿维巴坦钠操作简便，晶型稳定，具有广泛应用前景。

发明人： 温鸿亮，李可欣，尹江林，高杰

申请人： 北京理工大学

申请号： 202311091695.4

申请日期： 2023.08.28

摘要： 本发明涉及一种阿维巴坦单钠盐的新晶型及其制备方法。该方法制备阿维巴坦钠盐操作简便，晶型稳定，具有广泛应用前景。

作者： Gan, Qiaoyu^1,2;Liu, Haibo²;Jiang, Zeqi²;Xia, Junmei²;Gao, Zhenhua²;Guo, Yongbiao²;Wen, Hongliang¹ （¹Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R China.;²State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China.）

出处： CHEMICAL COMMUNICATIONS 2023

关键词： EN-ROUTE; DEAROMATIZATION; DESIGN; POTENT

摘要： We herein report a direct and efficient protocol for phosphorylation of quinoxalines, which employs aerobic oxygen as the green oxidant under catalyst ...

作者： Iqra Kalsoom;Yuanhao Wang;Bo Li;Hongliang Wen （¹ School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China. ² Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing, 100081, China. ³ Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.）

出处： Mini reviews in medicinal chemistry 2023

关键词： ?-Synuclein aggregation;Inhibitors;Parkinson’s disease;Presynaptic;Structure-activity relationship;Substantianigra;intrinsically disordered protein.

摘要： Introduction: Parkinson\'s disease (PD) is characterized by fibrillation of disordered proteins known as Lewy bodies in the substantia nigra that also ...

作者： 王朝阳，王源浩，杨吉霞，庆宏，温鸿亮 （北京理工大学化学与化工学院；北京理工大学生命学院）

出处： 中国药物化学杂志 2022 第32卷 第1期 P53-60

关键词： 帕金森氏病；alpha-突触核蛋白；寡聚体；抑制剂

摘要： 帕金森氏症(PD)是人类一种常见的神经系统疾病。目前,对于其致病机制虽不能完全阐明,但已发现其与黑质致密部中的多巴胺能神经元的变性缺失以及脑中细胞质的路易小体(LBs)的形成密切相关。研究发现,聚集的alpha-突触核蛋白(alpha-Syn)是LBs的主要成分,与PD的发病机制相关。传统治疗PD药 ...

作者： Wu, Dan¹²;Chen, Cong³;Liu, Changhao¹²;Wen, Hongliang¹²; （¹School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 102488, China;²Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Beijing, 102488, China;³School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Benxi, 117000, China）

出处： Yaoxue Xuebao 2021 Vol.56 No.10 P2769-2778

摘要： Cancer is a malignant disease threatening human health and life. Early diagnosis of carcinoma plays an important role in the treatment of carcinoma, s ...