发明人：朱长进，马兵，张新

申请日期：2020.12.08

摘要：本发明公开了一系列苯并噁唑酮类衍生物的结构、制备方法及用途，即提供了化合物Ⅰ所示苯并噁唑酮类化合物结构、合成方法、及其药学上可以接受的盐或它们的混合物在制备预防和/或治疗糖尿病并发症药物中的用途。这类化合物作为醛糖还原酶抑制剂和抗氧化剂，还具有降血糖效果。该类化合物可以降血糖，抑制醛糖还原酶的活性， ...

作者：Lingyun Li¹;Bing Ma¹;Weizhi Wang¹; （¹ School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.）

出处：Molecules (Basel, Switzerland) 2020

关键词：immune checkpoint blockade;peptide screening;peptide self-assembly;peptide-based nanomaterials.

摘要：With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a resear ...

作者：Li, Lingyun¹;Li, Mengzhen¹;Wang, Minxuan¹;Zhang, Limin¹;Yu, Yao¹;Zhang, Jiatao¹;CAa;Ma, Bing¹;CAb;Wang, Weizhi¹;CAc （¹Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science, Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, China）

出处：ACS Nano 2022

关键词：cancer immunotherapy;click chemistry;immune checkpoint blockade;molecular manipulation;PD-L1 degradation

摘要：Spatiotemporal manipulation of protein distributions, abundances, and functions based on molecular level remains a significant challenge in studying b ...