作者：Chanchan Yu，Kun Li，Lin Xu，Bo Li，Chunhui Li，Shuai Guo，Ziyue Li，Yuquan Zhang，Abid Hussain，Hong Tan，Mengyu Zhang，Yongxiang Zhao，Yuanyu Huang，Xing-Jie Liang （School of Life Science，Advanced Research Institute of Multidisciplinary Science，School of Medical Technology(Institute of Engineering Medicine)，Key Laboratory of Molecular Medicine and Biotherapy，Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering，Beijing Institute of Technology，Beijing 100081，China；CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety，CAS Center for Excellence in Nanoscience，National Center for Nanoscience and Technology of China，Beijing 100190，China；School of Life Science，Advanced Research Institute of Multidisciplinary Science，School of Medical Technology(Institute of Engineering Medicine)，Key Laboratory of Molecular Medicine and Biotherapy，Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering，Beijing Institute of Technology，Beijing 100081，China；National Center for International Research of Biological Targeting Diagnosis and Therapy，Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research，Guangxi Medical University，Nanning530021，China；CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety，CAS Center for Excellence in Nanoscience，National Center for Nanoscience and Technology of China，Beijing 100190，China）

出处：纳米研究(英文版) 2022

关键词：coordination；chemistry；nuclei；acid；lanthanide；nanomaterials；small；interfering；RNA(siRNA)delivery；endosome；escape

摘要：Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug delivery.Herein,we report that small interfering RNA(siRNA)ef ...

作者：Li, Chunhui;Yang, Tongren;Weng, Yuhua;Zhang, Mengjie;Zhao, Deyao;Guo, Shuai;Hu, Bo;Shao, Wanxuan;Wang, Xiaoxia;Hussain, Abid;Liang, Xingjie;Huang, Yuanyu （¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing, 100081, China;²Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou, 450000, China;³Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, 100871, China;⁴Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China;⁵School of Materials and the Environment, Beijing Institute of Technology, Zhuhai, 519085, China）

出处：Bioactive Materials 2022

摘要：CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool, that relies on Cas9 protein and single guided RNA (sgRNA) to edit targ ...

作者：Chanchan Yu;|Kun Li;|Lin Xu;|Bo Li;|Chunhui Li;|Shuai Guo;|Ziyue Li;|Yuquan Zhang;|Abid Hussain;|Hong Tan;|Mengyu Zhang;|Yongxiang Zhao;|Yuanyu Huang;|Xing-Jie Liang （¹School of Life Science, Advanced Research Institute of Multidisciplinary Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China;²CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China;³National Center for International Research of Biological Targeting Diagnosis and Therapy, Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Guangxi Medical University, Nanning, 530021, China）

出处：Nano Research 2022

关键词：coordination chemistry;nuclei acid;lanthanide nanomaterials;small interfering RNA (siRNA) delivery;endosome escape

摘要：Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug delivery. Herein, we report that small interfering RNA (siRNA ...

发明人：杨明辉，叶国国，黄渊余，李春辉

申请日期：2023.04.23

摘要：本发明涉及能特异性抑制寨卡病毒(ZIKV)、登革病毒(DENV)及黄热病毒(YFV)等黄病毒属感染的多肽以及药物组合物。本发明提供的该多肽包括寨卡病毒的衣壳蛋白或其片段，所述片段与寨卡病毒的衣壳蛋白二聚体结合。这对于黄病毒属感染的治疗，尤其是孕妇ZIKV感染的治疗显得尤为重要，可以作为预防或治疗ZI ...

发明人：杨明辉，叶国国，李春辉，黄渊余，赵梦圆，田雨欣

申请日期：2023.05.23

摘要：本公开涉及特异性结合冠状病毒核衣壳蛋白的核酸适配体。本公开的核酸适配体可以与冠状病毒核衣壳蛋白以高亲和力特异性结合，能够快速、高效的进入细胞发挥作用，并在较长时间内均可有效抑制冠状病毒的病毒复制与增殖；同时，本公开的核酸适配体在细胞内具有较好的安全性，是潜在的冠状病毒预防和治疗药物。

发明人：杨明辉，黄渊余，沈晨光，叶国国，李春辉，石慧萍，田雨欣，赵梦圆

申请日期：2023.06.02

摘要：本文提供了冠状病毒mRNA疫苗及其应用。本文的核酸分子编码能够引发针对冠状病毒的强效中和抗体反应的高免疫原性抗原，用于表达冠状病毒刺突(S)蛋白的关键中和结构域，当单独或组合用作免疫原性组合物或疫苗时，能有效诱导保护性免疫。